Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease: The Japan Epidemiology Collaboration on Occupational Health Study

被引：15

作者：

Hu, Huan ^{[1
,2
]}

Fukunaga, Ami ^{[2
]}

Yokoya, Toshitaka ^{[3
]}

Nakagawa, Tohru ^{[4
]}

Honda, Toru ^{[4
]}

Yamamoto, Shuichiro ^{[4
]}

Okazaki, Hiroko ^{[5
]}

Miyamoto, Toshiaki ^{[6
]}

Sasaki, Naoko ^{[7
]}

Ogasawara, Takayuki ^{[7
]}

Gonmori, Naoki ^{[8
]}

Yamamoto, Kenya ^{[9
]}

Hori, Ai ^{[10
]}

Tomita, Kentaro ^{[11
]}

Nagahama, Satsue ^{[12
]}

Konishi, Maki ^{[2
]}

Katayama, Nobumi ^{[2
]}

Morioka, Hisayoshi ^{[1
]}

Kabe, Isamu ^{[13
]}

Mizoue, Tetsuya ^{[2
]}

Dohi, Seitaro ^{[5
]}

机构：

[1] Tokushima Univ, Dept Publ Hlth, Grad Sch Biomed Sci, Tokushima, Japan

[2] Natl Ctr Global Hlth & Med, Dept Epidemiol & Prevent, Tokyo, Japan

[3] Mitsubishi Heavy Ind Co Ltd, Sagamihara, Kanagawa, Japan

[4] Hitachi Ltd, Hitachi Hlth Care Ctr, Hitachi, Ibaraki, Japan

[5] Mitsui Chem Inc, Tokyo, Japan

[6] East NIPPON Works Kimitsu Area, NIPPON Steel Corp, Chiba, Japan

[7] Mitsubishi Fuso Truck & Bus Corp, Kawasaki, Kanagawa, Japan

[8] JFE Steel Corp, East Japan Works Keihin, Yokohama, Kanagawa, Japan

[9] Natl Inst Occupat Safety & Hlth, Div Chem Informat, Kiyose, Kanagawa, Japan

[10] Univ Tsukuba, Fac Med, Dept Global Publ Hlth, Tsukuba, Ibaraki, Japan

[11] Healthplant Co Ltd, Tokyo, Japan

[12] All Japan Labour Welf Fdn, Tokyo, Japan

[13] KUBOTA Corp, Tokyo, Japan

来源：

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | 2022年 / 29卷 / 09期

基金：

日本学术振兴会;

关键词：

Non-high-density lipoprotein cholesterol; Stroke; Myocardial infarction; CORONARY-HEART-DISEASE; ARTERIAL STIFFNESS; POPULATION; METAANALYSIS; PEOPLE; TREND;

D O I：

10.5551/jat.63118

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Aims: We aimed to investigate the association between non-high-density lipoprotein cholesterol (non-HDL-C) levels and the risk of cardiovascular disease (CVD) and its subtypes. Methods: In this contemporary cohort study, we analyzed the data of 63,814 Japanese employees aged >= 30 years, without known CVD in 2012 and who were followed up for up to 8 years. The non-HDL-C level was divided into 5 groups: < 110, 110-129, 130-149, 150-169, and >= 170 mg/dL. The Cox proportional hazards model was used to calculate the hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) for CVD and its subtypes associated with each non-HDL-C group, considering 130-149 mg/dL as the reference group. Results: During the study period, 271 participants developed CVD, including 78 myocardial infarctions and 193 strokes (102 ischemic strokes, 89 hemorrhagic strokes, and 2 unknowns). A U-shaped association between non-HDL-C and stroke was observed. In the analysis of stroke subtypes, the multivariable-adjusted HR (95% CI) for hemorrhagic stroke was 2.61 (1.19-5.72), 2.02 (0.95-4.29), 2.10 (1.01-4.36), and 1.98 (0.96-4.08), while that for ischemic stroke was 1.54 (0.77-3.07), 0.91 (0.46-1.80), 0.73 (0.38-1.41), and 1.50 (0.87-2.56) in the < 110, 110-129, 150-169, and >= 170 mg/dL groups, respectively. Individuals with elevated non-HDL-C levels had a higher risk of myocardial infarction. Conclusions: High non-HDL-C levels were associated with an increased risk of myocardial infarction. Moreover, high and low non-HDL-C levels were associated with a high risk of stroke and its subtypes among Japanese workers.

引用

页码：1295 / 1306

页数：12

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