The Early Fracture Hematoma and Its Potential Role in Fracture Healing

被引：4

作者：

Kolar, Paula ^{[3
]}

Schmidt-Bleek, Katharina ^{[1
,2
]}

Schell, Hanna ^{[1
,2
]}

Gaber, Timo ^{[3
]}

Toben, Daniel ^{[1
,2
]}

Schmidmaier, Gerhard ^{[1
,2
]}

Perka, Carsten ^{[1
,2
]}

Buttgereit, Frank ^{[3
]}

Duda, Georg N. ^{[1
,2
]}

机构：

[1] Julius Wolff Inst, Berlin Brandenburg Ctr Regenerat Therapies, D-13353 Berlin, Germany

[2] Charite, Ctr Musculoskeletal, D-13353 Berlin, Germany

[3] Charite, Dept Rheumatol & Clin Immunol, D-13353 Berlin, Germany

来源：

TISSUE ENGINEERING PART B-REVIEWS | 2010年 / 16卷 / 04期

关键词：

IMMUNE-SYSTEM; BONE REPAIR; COLLAGEN-SYNTHESIS; TISSUE HEMATOMAS; PROGENITOR CELLS; OXYGEN-TENSION; DIFFERENTIATION; OSTEOIMMUNOLOGY; EXPRESSION; TRAUMA;

D O I：

10.1089/ten.teb.2009.0687

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Research regarding the potency and potential of the fracture hematoma has begun to receive increasing attention. However, currently there is a paucity of relevant literature on the capability and composition of the fracture hematoma. This review briefly summarizes the regenerative fracture healing process and the close interplay between the skeletal and immune systems. The role of immune cells in wound healing is also discussed to clarify their involvement in immunological processes during regeneration. We attempt to describe the current state of knowledge regarding the fracture hematoma as the initial stage of the regenerative process of fracture healing. The review discusses how a better understanding of immune reactions in the hematoma may have implications for bone tissue engineering strategies. We conclude the review by emphasizing how additional investigations of the initial phase of healing will allow us to better differentiate between deleterious and beneficial aspects of inflammation, thereby facilitating improved fracture treatment strategies.

引用

页码：427 / 434

页数：8

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