The telomere/telomerase system in autoimmune and systemic immune-mediated diseases

被引：93

作者：

Georgin-Lavialle, Sophie ^{[1
,2
]}

Aouba, Achille ^{[2
]}

Mouthon, Luc ^{[3
]}

Londono-Vallejo, J. Arturo ^{[4
]}

Lepelletier, Yves ^{[1
]}

Gabet, Anne-Sophie ^{[1
]}

Hermine, Olivier ^{[1
,2
]}

机构：

[1] Univ Paris 05, Fac Med, Hop Necker Enfants Malad,Assistance Publ Hop Pari, Mastocytosis Reference Ctr,CNRS,UMR 8147, F-75015 Paris, France

[2] Paris Descartes Univ, Fac Med, Necker Enfants Malad Hosp,Assistance Publ Hop Par, Dept Adult Haematol,Mastocytosis Reference Ctr, F-75015 Paris, France

[3] Univ Paris 05, French Natl Reference Ctr Syst Vasculitides, Hop Cochin,Assistance Publ Hop Paris, French Vasculitis Study Grp,Dept Internal Med, F-75679 Paris 14, France

[4] Inst Curie, Lab Telomeres & Canc, UMR3244, F-75248 Paris 05, France

来源：

AUTOIMMUNITY REVIEWS | 2010年 / 9卷 / 10期

关键词：

Telomere length; Telomerase activity; Inflammatory disease; Autoimmune disease; Systemic disease; BLOOD MONONUCLEAR-CELLS; LUPUS-ERYTHEMATOSUS; TELOMERASE ACTIVITY; RHEUMATOID-ARTHRITIS; T-CELLS; PULMONARY-FIBROSIS; LENGTH; SENESCENCE; SLE; DNA;

D O I：

10.1016/j.autrev.2010.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Telomeres are specialized nucleoproteic structures that cap and protect the ends of chromosomes. They can be elongated by the telomerase enzyme, but in telomerase negative cells, telomeres shorten after each cellular division because of the end replicating problem. This phenomenon leads ultimately to cellular senescence, conferring to the telomeres a role of biological clock. Oxidative stress, inflammation and increased cell renewal are supplementary environmental factors that accelerate age-related telomere shortening. Similar to other types of DNA damage, very short/dysfunctional telomeres activate a DNA response pathway leading to different outcomes: DNA repair, cell senescence or apoptosis. During the last 10 years, studies on the telomere/telomerase system in autoimmune and/or systemic immune-mediated diseases have revealed its involvement in relevant physiopathological processes. Here, we present a literature review of telomere and telomerase homeostasis in systemic inflammatory diseases including systemic lupus erythematosus, rheumatoid arthritis and granulomatous diseases. The available data indicate that both telomerase activity and telomere length are modified in various systemic immune-mediated diseases and appear to be connected with premature immunosenescence. Studies on the telomere/telomerase system open new research avenues for the basic understanding and for therapeutic approaches of these pathologies. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：646 / 651

页数：6

共 45 条

[41] Oxidative stress shortens telomeres [J].