Alteplase Treatment in Acute Stroke: Incorporating Food and Drug Administration Prescribing Information into Existing Acute Stroke Management Guide

被引：6
作者：
Demaerschalk, Bart M. [1 ,2 ]
机构：
[1] Mayo Clin, Rochester, MN 55905 USA
[2] Mayo Clin Hosp, 5777 East Mayo Blvd, Phoenix, AZ 85054 USA
来源：
CURRENT ATHEROSCLEROSIS REPORTS | 2016年 / 18卷 / 08期
关键词：
Alteplase; Tissue plasminogen activator; Ischemic stroke; Guidelines; Food and Drug Administration; ACUTE ISCHEMIC-STROKE; TISSUE-PLASMINOGEN ACTIVATOR; INTRAVENOUS THROMBOLYSIS; COMPUTED-TOMOGRAPHY; MILD STROKE; OUTCOMES;
D O I：
10.1007/s11883-016-0602-5
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Despite strong evidence that intravenous tissue plasminogen activator (tPA) improves outcomes in acute ischemic stroke patients, its use in clinical practice remains modest. Complex eligibility criteria have been postulated as barriers to greater utilization. Further complicating this has been multiple guidelines and prescribing labels that have been published since first being approved for use in 1996. In this review, several warning and exclusion criteria for tPA in acute ischemic stroke are reviewed with the goal of providing readers a nuanced understanding of historical context and available evidence to make informed decision.
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页数：6
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