Scintigraphic imaging of Staphylococcus aureus infection using 99mTc radiolabeled aptamers

被引：9
作者：
dos Santos, Sara Roberta [1 ]
de Sousa Lacerda, Camila Maria [1 ]
Ferreira, Ieda Mendes [1 ]
Branco de Barros, Andre Luis [2 ]
Fernandes, Simone Odilia [2 ]
Cardoso, Valbert Nascimento [2 ]
Ribeiro de Andrade, Antero Silva [1 ]
机构：
[1] CDTN, Rua Prof Mario Wemeck S-No,Campus UFMG, BR-31120970 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Fac Farm, Dept Anal Clin & Toxicol, Campus UFMG, BR-31270091 Belo Horizonte, MG, Brazil
来源：
APPLIED RADIATION AND ISOTOPES | 2017年 / 128卷
关键词：
Aptamer; Technetium-99m; Radiopharmaceutical; Bacterial infection; Diagnosis; RADIOPHARMACEUTICALS; THERAPY; BIODISTRIBUTION; INFLAMMATION; DIAGNOSIS; BACTERIAL;
D O I：
10.1016/j.apradiso.2017.06.043
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Staphylococcus aureus is a specie of great medical importance associated with many infections as bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device related infections. Early identification of infectious foci is crucial for successful treatment. Scintigraphy could contribute to this purpose since specific radiotracers were available. Aptamers due to their high specificity have great potential for radiopharmaceuticals development. In the present study scintigraphic images of S. aureus infectious foci were obtained using specific S. aureus aptamers radiolabeled with Tc-99m.
引用
收藏
页码：22 / 27
页数：6
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