Race and prostate cancer: genomic landscape

被引：21

作者：

Arenas-Gallo, Camilo ^{[1
]}

Owiredu, Jude ^{[2
]}

Weinstein, Ilon ^{[1
]}

Lewicki, Patrick ^{[2
]}

Basourakos, Spyridon P. ^{[2
]}

Vince, Randy, Jr. ^{[3
]}

Al Awamlh, Bashir Al Hussein ^{[2
,4
]}

Schumacher, Fredrick R. ^{[5
,6
]}

Spratt, Daniel E. ^{[7
]}

Barbieri, Christopher E. ^{[2
]}

Shoag, Jonathan E. ^{[1
,2
,6
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Urol, Univ Hosp Cleveland Med Ctr, Cleveland, OH 44106 USA

[2] Weill Cornell Med, Dept Urol, NewYork Presbyterian Hosp, New York, NY 10021 USA

[3] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[4] Vanderbilt Univ, Dept Urol, Med Ctr, Nashville, TN USA

[5] Case Western Reserve Univ, Sch Med, Dept Populat & Quantitat Hlth Sci, Cleveland, OH USA

[6] Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

[7] Case Western Reserve Univ, Sch Med, Dept Radiat Oncol, Univ Hosp Seidman Canc Ctr, Cleveland, OH USA

来源：

NATURE REVIEWS UROLOGY | 2022年 / 19卷 / 09期

关键词：

DIFFERENTIALLY METHYLATED GENES; AFRICAN-AMERICAN; HIGH-GRADE; HEALTH DISPARITIES; GERMLINE MUTATIONS; INTRAEPITHELIAL NEOPLASIA; DNA HYPOMETHYLATION; PROGNOSTIC VALUE; ERG ONCOPROTEIN; SPOP MUTATIONS;

D O I：

10.1038/s41585-022-00622-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In this Review, the authors discuss racial differences in the prevalence of genetic mutations in the main molecular drivers of prostate cancer and provide input regarding the role of genomics in racial disparities observed in prostate cancer outcomes. In the past 20 years, new insights into the genomic pathogenesis of prostate cancer have been provided. Large-scale integrative genomics approaches enabled researchers to characterize the genetic and epigenetic landscape of prostate cancer and to define different molecular subclasses based on the combination of genetic alterations, gene expression patterns and methylation profiles. Several molecular drivers of prostate cancer have been identified, some of which are different in men of different races. However, the extent to which genomics can explain racial disparities in prostate cancer outcomes is unclear. Future collaborative genomic studies overcoming the underrepresentation of non-white patients and other minority populations are essential.

引用

页码：547 / 561

页数：15

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