Analysis of C-850T and G-308A polymorphisms of the tumor necrosis factor-α gene in Maya-Mestizo women with preeclampsia

被引：18

作者：

Canto-Cetina, Thelma

Canizales-Quinteros, Samuel

de la Chesnaye, Elsa

Coral-Vazquez, Ramon

Mendez, Juan Pablo

Canto, Patricia

机构：

[1] Inst Mexicano Seguro Social, Coordinac Invest Salud, Ctr Med Nacl Siglo 21, Unidad Invest Med Biol Desarrollao, Mexico City 06703, DF, Mexico

[2] Inst Mexicano Seguro Social, Hosp Pediat, Ctr Med Nacl Siglo 21, Unidad Invest Med Genet Humana, Mexico City, DF, Mexico

[3] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Biol Mol & Med Genom, Mexico City, DF, Mexico

[4] Ctr Invest Reg Dr Hideyo Noguchi, Dept Salud Reprod & Genet, Reprod Biol Lab, Mexico City, DF, Mexico

来源：

HYPERTENSION IN PREGNANCY | 2007年 / 26卷 / 03期

关键词：

C-850T polymorphism; G-308A polymorphism; Maya-Mestizo women; promoter of the TNF-alpha; preeclampsia; TNF-ALPHA; INSULIN-RESISTANCE; EXPRESSION; HAPLOTYPE; INTERLEUKIN-1-BETA; ASSOCIATION; FREQUENCIES; PREGNANCY; CYTOKINES; MARKERS;

D O I：

10.1080/10641950701372732

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

To determine whether polymorphisms in the TNF-alpha promoter gene are associated with preeclampsia. Methods: 105 women with preeclampsia and 200 controls were genotyped for the G-308A and C-850T polymorphisms by RFLP. Differences in allele, genotype, and haplotype frequencies between groups were assessed. Results: The genotypic and allelic distribution of both polymorphisms was similar between groups. Moreover, the estimated overall pair of loci haplotype frequencies did not differ significantly. Conclusion: We did not find any association between these polymorphisms and the risk for preeclampsia. However, we found that both the genotypic and allelic distribution in our population differed from those reported in other populations.

引用

页码：283 / 291

页数：9

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