Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

被引:680
作者
Desforges, Marc [1 ]
Le Coupanec, Alain [1 ]
Dubeau, Philippe [1 ]
Bourgouin, Andreanne [1 ]
Lajoie, Louise [2 ]
Dube, Mathieu [1 ,3 ]
Talbot, Pierre J. [1 ]
机构
[1] Univ Quebec, INRS, Lab Neuroimmunovirol, Inst Armand Frappier, Laval, PQ H7V 1B7, Canada
[2] Univ Sherbrooke, Fac Med & Sci Sante, Sherbrooke, PQ J1K 2R1, Canada
[3] Ctr Hosp Univ Montreal, Res Ctr, CRCHUM, Montreal, PQ H3T 1J4, Canada
来源
VIRUSES-BASEL | 2020年 / 12卷 / 01期
基金
加拿大健康研究院;
关键词
human respiratory virus; human coronavirus; respiratory viral infection; neuroinvasion; CNS infection; acute and chronic neurological diseases; encephalitis; encephalopathy; INFLUENZA-A VIRUS; HIPPOCAMPAL NEURON MORPHOLOGY; CELL TRANSPLANT RECIPIENTS; BLOOD-BRAIN-BARRIER; MERS-COV OUTBREAK; RNASE L PATHWAY; SYNCYTIAL VIRUS; VIRAL-INFECTIONS; MULTIPLE-SCLEROSIS; NIPAH VIRUS;
D O I
10.3390/v12010014
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). Respiratory viruses can also exacerbate asthma and lead to various types of respiratory distress syndromes. Furthermore, as they can adapt fast and cross the species barrier, some of these pathogens, like influenza A and SARS-CoV, have occasionally caused epidemics or pandemics, and were associated with more serious clinical diseases and even mortality. For a few decades now, data reported in the scientific literature has also demonstrated that several respiratory viruses have neuroinvasive capacities, since they can spread from the respiratory tract to the central nervous system (CNS). Viruses infecting human CNS cells could then cause different types of encephalopathy, including encephalitis, and long-term neurological diseases. Like other well-recognized neuroinvasive human viruses, respiratory viruses may damage the CNS as a result of misdirected host immune responses that could be associated with autoimmunity in susceptible individuals (virus-induced neuro-immunopathology) and/or viral replication, which directly causes damage to CNS cells (virus-induced neuropathology). The etiological agent of several neurological disorders remains unidentified. Opportunistic human respiratory pathogens could be associated with the triggering or the exacerbation of these disorders whose etiology remains poorly understood. Herein, we present a global portrait of some of the most prevalent or emerging human respiratory viruses that have been associated with possible pathogenic processes in CNS infection, with a special emphasis on human coronaviruses.
引用
收藏
页数:28
相关论文
共 327 条
  • [61] Influenza Viral RNA Detection in Blood as a Marker to Predict Disease Severity in Hematopoietic Cell Transplant Recipients
    Choi, Su-Mi
    Xie, Hu
    Campbell, Angela P.
    Kuypers, Jane
    Leisenring, Wendy
    Boudreault, Alexandre A.
    Englund, Janet A.
    Corey, Lawrence
    Boeckh, Michael
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2012, 206 (12) : 1872 - 1877
  • [62] Acute Flaccid Myelitis Associated With Enterovirus D68: A Review
    Christy, Alison
    Messacar, Kevin
    [J]. JOURNAL OF CHILD NEUROLOGY, 2019, 34 (09) : 511 - 516
  • [63] Emergence of the Middle East Respiratory Syndrome Coronavirus
    Coleman, Christopher M.
    Frieman, Matthew B.
    [J]. PLOS PATHOGENS, 2013, 9 (09)
  • [64] In vitro detection of apoptosis in monocytes/macrophages infected with human coronavirus
    Collins, AR
    [J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2002, 9 (06) : 1392 - 1395
  • [65] Hosts and Sources of Endemic Human Coronaviruses
    Corman, Victor M.
    Muth, Doreen
    Niemeyer, Daniela
    Drosten, Christian
    [J]. ADVANCES IN VIRUS RESEARCH, VOL 100, 2018, 100 : 163 - 188
  • [66] Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus
    Cotten, Matthew
    Watson, Simon J.
    Zumla, Alimuddin I.
    Makhdoom, Hatem Q.
    Palser, Anne L.
    Ong, Swee Hoe
    Al Rabeeah, Abdullah A.
    Alhakeem, Rafat F.
    Assiri, Abdullah
    Al-Tawfiq, Jaffar A.
    Albarrak, Ali
    Barry, Mazin
    Shibl, Atef
    Alrabiah, Fahad A.
    Hajjar, Sami
    Balkhy, Hanan H.
    Flemban, Hesham
    Rambaut, Andrew
    Kellam, Paul
    Memish, Ziad A.
    [J]. MBIO, 2014, 5 (01):
  • [67] Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study
    Cotten, Matthew
    Watson, Simon J.
    Kellam, Paul
    Al-Rabeeah, Abdullah A.
    Makhdoom, Hatem Q.
    Assiri, Abdullah
    Al-Tawfiq, Jaffar A.
    Alhakeem, Rafat F.
    Madani, Hossam
    AlRabiah, Fahad A.
    Al Hajjar, Sami
    Al-Nassir, Wafa N.
    Albarrak, Ali
    Flemban, Hesham
    Balkhy, Hanan H.
    Alsubaie, Sarah
    Palser, Anne L.
    Gall, Astrid
    Bashford-Rogers, Rachael
    Rambaut, Andrew
    Zumla, Alimuddin I.
    Memish, Ziad A.
    [J]. LANCET, 2013, 382 (9909) : 1993 - 2002
  • [68] A mouse model for chikungunya:: Young age and inefficient type-I interferon signaling are risk factors for severe disease
    Couderc, Therese
    Chretien, Fabrice
    Schilte, Clementine
    Disson, Olivier
    Brigitte, Madly
    Guivel-Benhassine, Florence
    Touret, Yasmina
    Barau, Georges
    Cayet, Nadege
    Schuffenecker, Isabelle
    Despres, Philippe
    Arenzana-Seisdedos, Fernando
    Michault, Alain
    Albert, Matthew L.
    Lecuit, Marc
    [J]. PLOS PATHOGENS, 2008, 4 (02)
  • [69] Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma The Role of Metapneumovirus, Bocavirus and Influenza Virus
    Coverstone, Andrea M.
    Wang, Leyao
    Sumino, Kaharu
    [J]. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2019, 39 (03) : 391 - +
  • [70] Cristallo A, 1997, MICROBIOLOGICA, V20, P105