Removal of morphine with the new high-efficiency and high-flux membranes during haemofiltration and haemodialfiltration

被引：15
|
作者：
Jamal, JA [1 ]
Joh, J [1 ]
Bastani, B [1 ]
机构：
[1] St Louis Univ, Hlth Sci Ctr, Div Nephrol, St Louis, MO 63103 USA
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 1998年 / 13卷 / 06期
关键词：
morphine; dialysis; haemofiltration; haemodiafiltration; toxicity;
D O I：
10.1093/ndt/13.6.1535
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
We present three critically ill patients with severe renal failure who required haemofiltration or haemodiafiltration, with high-efficiency or high-flux membranes, while receiving an intravenous infusion of morphine. We show that despite the very high ultra-filtrability/diffusability of free morphine, only 1-3% of the total amount of infused morphine is removed in 24 h. This is in marked contrast to haemodialysis where, owing to much higher dialysate flow rate, a significant quantity of free morphine is removed.
引用
收藏
页码：1535 / 1537
页数：3
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