Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity

被引：372
作者：
Shetty, Shishir [1 ,2 ,3 ]
Lalor, Patricia F. [1 ,2 ,3 ]
Adams, David H. [1 ,2 ,3 ]
机构：
[1] Univ Birmingham, Ctr Liver Res, Birmingham, W Midlands, England
[2] Univ Birmingham, Inst Immunol & Immunotherapy, NIHR Birmingham Biomed Res Ctr, Birmingham, W Midlands, England
[3] Univ Hosp Birmingham NHS Trust, Liver Unit, Birmingham, W Midlands, England
来源：
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2018年 / 15卷 / 09期
关键词：
VASCULAR ADHESION PROTEIN-1; CD8(+) T-CELLS; TRANSENDOTHELIAL MIGRATION; INFLAMED LIVER; DC-SIGNR; CXCR3-DEPENDENT RECRUITMENT; INFILTRATING LYMPHOCYTES; IMMUNODEFICIENCY-VIRUS; CROSS-PRESENTATION; MANNOSE RECEPTOR;
D O I：
10.1038/s41575-018-0020-y
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do not simply form a barrier within the hepatic sinusoids but have vital physiological and immunological functions, including filtration, endocytosis, antigen presentation and leukocyte recruitment. Reflecting these multifunctional properties, LSECs display unique structural and phenotypic features that differentiate them from the capillary endothelium present within other organs. It is now clear that LSECs have a critical role in maintaining immune homeostasis within the liver and in mediating the immune response during acute and chronic liver injury. In this Review, we outline how LSECs influence the immune microenvironment within the liver and discuss their contribution to immune-mediated liver diseases and the complications of fibrosis and carcinogenesis.
引用
收藏
页码：555 / 567
页数：13
相关论文
共 176 条
[1]   Expression of E-selectin and E-selectin ligands in human liver inflammation [J].
Adams, DH ;
Hubscher, SG ;
Fisher, NC ;
Williams, A ;
Robinson, M .
HEPATOLOGY, 1996, 24 (03) :533-538
[2]   Hepatic expression of macrophage inflammatory protein-1 alpha and macrophage inflammatory protein-1 beta after liver transplantation [J].
Adams, DH ;
Hubscher, S ;
Fear, J ;
Johnston, J ;
Shaw, S ;
Afford, S .
TRANSPLANTATION, 1996, 61 (05) :817-825
[3]  
Afford SC, 1998, J PATHOL, V186, P82, DOI 10.1002/(SICI)1096-9896(199809)186:1<82::AID-PATH151>3.0.CO
[4]  
2-D
[5]   Deconvoluting hepatic processing of carbon nanotubes [J].
Alidori, Simone ;
Bowman, Robert L. ;
Yarilin, Dmitry ;
Romin, Yevgeniy ;
Barlas, Afsar ;
Mulvey, J. Justin ;
Fujisawa, Sho ;
Xu, Ke ;
Ruggiero, Alessandro ;
Riabov, Vladimir ;
Thorek, Daniel L. J. ;
Ulmert, Hans David S. ;
Brea, Elliott J. ;
Behling, Katja ;
Kzhyshkowska, Julia ;
Manova-Todorova, Katia ;
Scheinberg, David A. ;
McDevitt, Michael R. .
Nature Communications, 2016, 7
[6]  
Arii S, 2000, J Hepatobiliary Pancreat Surg, V7, P40, DOI 10.1007/s005340050152
[7]   CX3CR1 and Vascular Adhesion Protein-1-Dependent Recruitment of CD16+ Monocytes Across Human Liver Sinusoidal Endothelium [J].
Aspinall, Alexander I. ;
Curbishley, Stuart M. ;
Lalor, Patricia F. ;
Weston, Chris J. ;
Blahova, Miroslava ;
Liaskou, Evaggelia ;
Adams, Rebecca M. ;
Holt, Andrew P. ;
Adams, David H. .
HEPATOLOGY, 2010, 51 (06) :2030-2039
[8]   Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation [J].
Barreiro, O ;
Yáñez-Mó, M ;
Sala-Valdés, M ;
Gutiérrez-López, MD ;
Ovalle, S ;
Higginbottom, A ;
Monk, PN ;
Cabañas, C ;
Sánchez-Madrid, F .
BLOOD, 2005, 105 (07) :2852-2861
[9]   Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms [J].
Barreiro, Olga ;
Zamai, Moreno ;
Yanez-Mo, Maria ;
Tejera, Emilio ;
Lopez-Romero, Pedro ;
Monk, Peter N. ;
Gratton, Enrico ;
Caiolfa, Valeria R. ;
Sanchez-Madrid, Francisco .
JOURNAL OF CELL BIOLOGY, 2008, 183 (03) :527-542
[10]   A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection [J].
Bashirova, AA ;
Geijtenbeek, TBH ;
van Duijnhoven, GCF ;
van Vliet, SJ ;
Eilering, JBG ;
Martin, MP ;
Wu, L ;
Martin, TD ;
Viebig, N ;
Knolle, PA ;
KewalRamani, VN ;
van Kooyk, Y ;
Carrington, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (06) :671-678
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