Imaging port wine stains by fiber optical coherence tomography

被引：39

作者：

Zhao, Shiyong ^{[1
]}

Gu, Ying ^{[1
,2
]}

Xue, Ping ^{[3
]}

Guo, Jin ^{[4
,5
]}

Shen, Tingmei ^{[1
,2
]}

Wang, Tianshi ^{[3
]}

Huang, Naiyan ^{[2
]}

Zhang, Li ^{[5
,6
]}

Qiu, Haixia ^{[2
]}

Yu, Xin ^{[1
]}

Wei, Xunbin ^{[5
,6
]}

机构：

[1] Beijing Inst Technol, Dept Optoelect, Beijing 100081, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China

[3] Tsinghua Univ, Dept Phys, Beijing 100081, Peoples R China

[4] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[5] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

[6] Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2010年 / 15卷 / 03期

基金：

中国国家自然科学基金;

关键词：

optical coherence tomography; port wine stains; photodynamic therapy; PULSED DYE-LASER; VIVO HUMAN SKIN; PHOTODYNAMIC THERAPY; PHOTORADIATION THERAPY; REFRACTIVE-INDEX; BLOOD-VESSELS; DELAY-LINE; IRRADIATION; WAVELENGTHS; DISPERSION;

D O I：

10.1117/1.3445712

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We develop a fiber optical coherence tomography (OCT) system in the clinical utility of imaging port wine stains (PWS). We use our OCT system on 41 patients with PWS to document the difference between PWS skin and contralateral normal skin. The system, which operates at 4 frames/s with axial and transverse resolutions of 10 and 9 mu m, respectively, in the skin tissue, can clearly distinguish the dilated dermal blood vessels from normal tissue. We present OCT images of patients with PWS and normal human skin. We obtain the structural parameters, including epidermal thickness and diameter and depth of dilated blood vessels. We demonstrate that OCT may be a useful tool for the noninvasive imaging of PWS. It may help determine the photosensitizer dose and laser parameters in photodynamic therapy for treating port wine stains. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3445712]

引用

页数：6

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