Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation

被引：463
作者：
Brownell, JE
Allis, CD
机构：
[1] Department of Biology, University of Rochester, Rochester
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 02期
关键词：
D O I：
10.1016/S0959-437X(96)80048-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Post-translational acetylation of the core histone amino-terminal tails has long been associated with both chromatin assembly and the regulation of gene expression. The recent identification and cloning of histone acetyltransferase genes represents a significant breakthrough in our understanding of how specific acetylation states are established. Ongoing characterization of these enzymes and their molecular cohorts supports a direct role for acetylation in a signaling pathway that modulates chromatin structure to create new patterns of transcription.
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收藏
页码：176 / 184
页数：9
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