Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

被引：30

作者：

Faulkner, Nikhil ^{[1
,2
]}

Ng, Kevin W. ^{[1
]}

Wu, Mary Y. ^{[3
]}

Harvey, Ruth ^{[4
]}

Margaritis, Marios ^{[5
]}

Paraskevopoulou, Stavroula ^{[5
]}

Houlihan, Catherine ^{[5
,6
]}

Hussain, Saira ^{[4
,7
]}

Greco, Maria ^{[7
]}

Bolland, William ^{[1
]}

Warchal, Scott ^{[3
]}

Heaney, Judith ^{[5
]}

Rickman, Hannah ^{[5
]}

Spyer, Moria ^{[5
,8
]}

Frampton, Daniel ^{[6
]}

Byott, Matthew ^{[5
]}

de Oliveira, Tulio ^{[9
,10
,11
,12
]}

Sigal, Alex ^{[9
,13
,14
]}

Kjaer, Svend ^{[15
]}

Swanton, Charles ^{[16
]}

Gandhi, Sonia ^{[17
]}

Beale, Rupert ^{[18
]}

Gamblin, Steve J. ^{[19
]}

McCauley, John W. ^{[4
]}

Daniels, Rodney Stuart ^{[4
]}

Howell, Michael ^{[3
]}

Bauer, David ^{[7
]}

Nastouli, Eleni ^{[1
,5
,8
]}

Kassiotis, George ^{[1
,20
]}

机构：

[1] Retroviral Immunol, London, England

[2] Imperial Coll London, Natl Heart & Lung Inst, London, England

[3] High Throughput Screening STP, London, England

[4] Worldwide Influenza Ctr, London, England

[5] UCLH NHS Trust, Adv Pathogen Diagnost Unit, London, England

[6] Div Infect & Immun, London, England

[7] RNA Virus Replicat Lab, London, England

[8] Dept Populat Policy & Practice, London, England

[9] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Durban, South Africa

[10] KwaZulu Natal Res Innovat & Sequencing Platform, Durban, South Africa

[11] Ctr AIDS Programme Res South Africa, Durban, South Africa

[12] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[13] Africa Hlth Res Inst, Durban, South Africa

[14] Max Planck Inst Infect Biol, Berlin, Germany

[15] Struct Biol STP, London, England

[16] Canc Evolut & Genome Instabil Lab, London, England

[17] Neurodegradat Biol Lab, London, England

[18] Cell Biol Infect Lab, London, England

[19] Francis Crick Inst, Struct Biol Dis Proc Lab, London, England

[20] Imperial Coll London, Dept Infect Dis, St Marys Hosp, London, England

来源：

ELIFE | 2021年 / 10卷

关键词：

VARIANT; LONDON;

D O I：

10.7554/eLife.69317

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: The degree of heterotypic immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging variants and the success of vaccination campaigns, but remains incompletely understood. Methods: We examined the immunogenicity of SARS-CoV-2 variant B.1.1.7 (Alpha) that arose in the United Kingdom and spread globally. We determined titres of spike glycoprotein-binding antibodies and authentic virus neutralising antibodies induced by B.1.1.7 infection to infer homotypic and heterotypic immunity. Results: Antibodies elicited by B.1.1.7 infection exhibited significantly reduced recognition and neutralisation of parental strains or of the South Africa variant B.1.351 (Beta) than of the infecting variant. The drop in cross-reactivity was significantly more pronounced following B.1.1.7 than parental strain infection. Conclusions: The results indicate that heterotypic immunity induced by SARS-CoV-2 variants is asymmetric.

引用

页数：12

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