Noncoding RNAs Involved in Mammary Gland Development and Tumorigenesis: There's a Long Way to Go

被引：48

作者：

Shore, Amy N. ^{[1
]}

Herschkowitz, Jason I. ^{[2
]}

Rosen, Jeffrey M. ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2012年 / 17卷 / 01期

关键词：

Noncoding RNA; Mammary gland development; Alveologenesis; Epigenetics; Breast cancer; EPITHELIAL-MESENCHYMAL TRANSITION; X-CHROMOSOME INACTIVATION; GENE-EXPRESSION; POTENTIAL MARKER; ACTIVATOR SRA; TARGET GENE; KEY STAGES; BC200; RNA; CELL FATE; BREAST;

D O I：

10.1007/s10911-012-9247-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mammalian genome encodes thousands of noncoding RNAs. These noncoding transcripts are broadly categorized into short noncoding RNAs, such as microRNAs (miRNAs), and long noncoding RNAs (lncRNAs) of greater than 200 nt. While the role of miRNAs in development and cancer biology has been extensively studied, much less is known about the vast majority of noncoding transcripts represented by lncRNAs. LncRNAs are emerging as key regulators of developmental processes and as such, their frequent misregulation in tumorigenesis and disease in not unexpected. The role of lncRNAs in mammary gland development and breast cancer is just beginning to be elucidated. This review will discuss the role of lncRNAs in mammalian and mammary gland development. In addition, we will review the contributions of lncRNAs to the stepwise progression of tumorigenesis, highlighting the role of lncRNAs in breast cancer.

引用

页码：43 / 58

页数：16

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