Dual band dual focus optical coherence tomography for imaging the whole eye segment

被引:30
作者
Fan, Shanhui [1 ]
Li, Lin [1 ]
Li, Qian [1 ]
Dai, Cuixia [1 ]
Ren, Qiushi [2 ]
Jiao, Shuliang [3 ]
Zhou, Chuanqing [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200240, Peoples R China
[2] Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China
[3] Florida Int Univ, Dept Biomed Engn, Miami, FL 33174 USA
来源
BIOMEDICAL OPTICS EXPRESS | 2015年 / 6卷 / 07期
基金
中国国家自然科学基金;
关键词
AXIAL LENGTH CHANGES; SPECTRAL-DOMAIN OCT; ANTERIOR SEGMENT; ACCOMMODATION; BIOMETRY; SHAPE;
D O I
10.1364/BOE.6.002481
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We developed an improved dual band dual focus spectral domain optical coherence tomography (SD-OCT) for in vivo 2D/3D imaging of the whole eye segment, including the whole anterior segment and retina. The system featured two OCT channels with two different bands centered at 840 nm and 1050 nm, which were designed to image the retina and the anterior segments of the eye, respectively. By combing the two probe light beams for co-axial scanning and separating them for focusing at different segments of the eye with a combination of three dichroic mirrors, we not only minimized the loss of the backscattered light from the sample but also improved the imaging depth, scan range and resolution. The full resolved complex (FRC) method was applied to double the imaging depth for the whole anterior segment imaging, with which an imaging depth of 36.71 mm in air was achieved. We demonstrated that this system was capable of measuring the dynamic changes of ocular dimensions, including the asphericity of the cornea and lens, during accommodation. (C) 2015 Optical Society of America
引用
收藏
页码:2481 / 2493
页数:13
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