Telomere length and iPSC re-programming: survival of the longest

被引：16

作者：

Allsopp, Richard ^{[1
]}

机构：

[1] Univ Hawaii, John A Burns Sch Med, Inst Biogenesis Res, Honolulu, HI 96813 USA

来源：

CELL RESEARCH | 2012年 / 22卷 / 04期

关键词：

MOUSE CELLS LACKING;

D O I：

10.1038/cr.2012.6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A hallmark feature of pluripotent stem cells is the ability to proliferate indefinitely (immortal phenotype). Despite reactivation of telomerase during iPSC derivation, there exists considerable heterogeneity in telomere length amongst established iPSC cell lines. Both telomerase-dependent and -independent mechanisms have now been shown to be important for continuous self-renewal of iPSC via the maintenance or extension of telomere length.

引用

页码：614 / 615

页数：2

共 10 条

[1] Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells [J].

Batista, Luis F. Z. ;

Pech, MatthewF. ;

Zhong, Franklin L. ;

Nguyen, Ha Nam ;

Xie, Kathleen T. ;

Zaug, Arthur J. ;

Crary, Sharon M. ;

Choi, Jinkuk ;

Sebastiano, Vittorio ;

Cherry, Athena ;

Giri, Neelam ;

Wernig, Marius ;

Alter, Blanche P. ;

Cech, Thomas R. ;

Savage, Sharon A. ;

Pera, Renee A. Reijo ;

Artandi, Steven E. .

NATURE, 2011, 474 (7351) :399-+

[2] Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [J].

Blasco, MA ;

Lee, HW ;

Hande, MP ;

Samper, E ;

Lansdorp, PM ;

DePinho, RA ;

Greider, CW .

CELL, 1997, 91 (01) :25-34

[3] Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells [J].

Marion, Rosa M. ;

Strati, Katerina ;

Li, Han ;

Tejera, Agueda ;

Schoeftner, Stefan ;

Ortega, Sagrario ;

Serrano, Manuel ;

Blasco, Maria A. .

CELL STEM CELL, 2009, 4 (02) :141-154

[4] Severe growth defect in mouse cells lacking the telomerase RNA component [J].

Niida, H ;

Matsumoto, T ;

Satoh, H ;

Shiwa, M ;

Tokutake, Y ;

Furuichi, Y ;

Shinkai, Y .

NATURE GENETICS, 1998, 19 (02) :203-206

[5]

Park IH, 2008, NATURE, V451, P141, DOI [10.1038/nature06534, 10.1038/natureO6534]

[6] Induction of pluripotent stem cells from adult human fibroblasts by defined factors [J].

Takahashi, Kazutoshi ;

Tanabe, Koji ;

Ohnuki, Mari ;

Narita, Megumi ;

Ichisaka, Tomoko ;

Tomoda, Kiichiro ;

Yamanaka, Shinya .

CELL, 2007, 131 (05) :861-872

[7] Embryonic stem cell lines derived from human blastocysts [J].

Thomson, JA ;

Itskovitz-Eldor, J ;

Shapiro, SS ;

Waknitz, MA ;

Swiergiel, JJ ;

Marshall, VS ;

Jones, JM .

SCIENCE, 1998, 282 (5391) :1145-1147

[8] Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells [J].

Wang, Fang ;

Yin, Yu ;

Ye, Xiaoying ;

Liu, Kai ;

Zhu, Haiying ;

Wang, Lingling ;

Chiourea, Maria ;

Okuka, Maja ;

Ji, Guangzhen ;

Dan, Jiameng ;

Zuo, Bingfeng ;

Li, Minshu ;

Zhang, Qian ;

Liu, Na ;

Chen, Lingyi ;

Pan, Xinghua ;

Gagos, Sarantis ;

Keefe, David L. ;

Liu, Lin .

CELL RESEARCH, 2012, 22 (04) :757-768

[9] Kruppel-Like Transcription Factor 4 Contributes to Maintenance of Telomerase Activity in Stem Cells [J].

Wong, Chui-Wei ;

Hou, Pei-Shan ;

Tseng, Shun-Fu ;

Chien, Chung-Liang ;

Wu, Kou-Juey ;

Chen, Hsin-Fu ;

Ho, Hong-Nerng ;

Kyo, Satoru ;

Teng, Shu-Chun .

STEM CELLS, 2010, 28 (09) :1510-1517

[10] Zscan4 regulates telomere elongation and genomic stability in ES cells [J].

Zalzman, Michal ;

Falco, Geppino ;

Sharova, Lioudmila V. ;

Nishiyama, Akira ;

Thomas, Marshall ;

Lee, Sung-Lim ;

Stagg, Carole A. ;

Hoang, Hien G. ;

Yang, Hsih-Te ;

Indig, Fred E. ;

Wersto, Robert P. ;

Ko, Minoru S. H. .

NATURE, 2010, 464 (7290) :858-U66

← 1 →