Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species

被引：79
作者：
Benchoam, Dayana [1 ,2 ]
Cuevasanta, Ernesto [1 ,2 ,3 ]
Moller, Matias N. [2 ,4 ]
Alvarez, Beatriz [1 ,2 ]
机构：
[1] Univ Republica, Inst Quim Biol, Fac Ciencias, Lab Enzimol, Montevideo 11400, Uruguay
[2] Univ Republica, Ctr Free Rad & Biomed Res, Montevideo 11800, Uruguay
[3] Univ Republica, Fac Ciencias, Ctr Invest Nucl, Unidad Bioquim Analit, Montevideo 11400, Uruguay
[4] Univ Republica, Inst Quim Biol, Fac Ciencias, Lab Fisicoquim Biol, Montevideo 11400, Uruguay
来源：
ANTIOXIDANTS | 2019年 / 8卷 / 02期
关键词：
hydrogen sulfide; persulfide; hydropersulfide; reactive oxygen species; sulfiyl radical; ISCHEMIA-REPERFUSION INJURY; CYSTATHIONINE BETA-SYNTHASE; ARALKYL HYDRODISULFIDES; CHEMICAL BIOLOGY; CYSTEINE PERSULFIDES; S-SULFHYDRATION; SULFANE SULFUR; NITRIC-OXIDE; MITOCHONDRIAL DYSFUNCTION; PULMONARY-FIBROSIS;
D O I：
10.3390/antiox8020048
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hydrogen sulfide (H2S/HS-) can be formed in mammalian tissues and exert physiological effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) and sulfenic acids (RSOH). Reactions with oxidized thiol products form persulfides (RSSH/RSS-). Persulfides have been proposed to transduce the signaling effects of H2S through the modification of critical cysteines. They are more nucleophilic and acidic than thiols and, contrary to thiols, also possess electrophilic character. In this review, we summarize the biochemistry of hydrogen sulfide and persulfides, focusing on redox aspects. We describe biologically relevant one- and two-electron oxidants and their reactions with H2S and persulfides, as well as the fates of the oxidation products. The biological implications are discussed.
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页数：23
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