Advances in the study of HLA class Ib in maternal-fetal immune tolerance

被引：9

作者：

Yang, Yiran ^{[1
]}

Wang, Wanning ^{[1
]}

Weng, Jing ^{[2
]}

Li, Huifang ^{[3
]}

Ma, Yanmin ^{[4
]}

Liu, Lingyan ^{[1
]}

Ma, Wei ^{[2
]}

机构：

[1] Capital Med Univ, Engn Res Ctr Endogenous Prophylact, Beijing Area Major Lab Peptide & Small Mol Drugs, Minist Educ China,Sch Pharmaceut Sci, Beijing, Peoples R China

[2] Capital Med Univ, Sch Basic Med Sci, Beijing, Peoples R China

[3] Capital Med Univ, Sch Tradit Chinese Med, Beijing, Peoples R China

[4] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

HLA class Ib; HLA-G; HLA-E; HLA-F; pregnancy; maternal-fetal immune tolerance; decidual immune cells; NATURAL-KILLER-CELLS; REGULATORY T-CELLS; ANTIGEN-PRESENTING CELLS; UTERINE NK CELLS; ACTIVATING RECEPTOR; INHIBITORY RECEPTOR; PREGNANCY SUCCESS; OPEN CONFORMERS; EXPRESSION; CD94/NKG2A;

D O I：

10.3389/fimmu.2022.976289

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction.

引用

页数：12

共 50 条

[21] The hidden maternal-fetal interface: events involving the lymphoid organs in maternal-fetal tolerance
Taglauer, Elizabeth S.
Waldorf, Kristina M. Adams
Petroff, Margaret G.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2010, 54 (2-3): : 421 - 430
[22] Research progress of maternal-fetal tolerance
Wang S.
Du M.
Li D.
Li, Dajin (djli@shmu.edu.cn), 2016, Chinese Academy of Sciences (61): : 2996 - 3001
[23] Fetal Surgical conditions and the unraveling of maternal-fetal tolerance
MacKenzie, Tippi C.
JOURNAL OF PEDIATRIC SURGERY, 2016, 51 (02) : 197 - 199
[24] Immune interactions at the maternal-fetal interface
Petroff, MG
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2005, 68 (1-2) : 1 - 13
[25] PRENATAL EFFECTS OF MATERNAL-FETAL HLA COMPATIBILITY
OBER, C
SIMPSON, JL
WARD, M
RADVANY, RM
ANDERSEN, R
ELIAS, S
SABBAGHA, R
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY AND MICROBIOLOGY, 1987, 15 (04): : 141 - 149
[26] Immune responses at the maternal-fetal interface
Ander, Stephanie E.
Diamond, Michael S.
Coyne, Carolyn B.
SCIENCE IMMUNOLOGY, 2019, 4 (31)
[27] MATERNAL-FETAL INTERACTIONS AND THE MAINTENANCE OF HLA POLYMORPHISM
HEDRICK, PW
THOMSON, G
GENETICS, 1988, 119 (01) : 205 - 212
[28] Maternal-fetal tolerance: Not just a uterine affair
Boly, Timothy J.
Bermick, Jennifer R.
JOURNAL OF LEUKOCYTE BIOLOGY, 2022, 111 (03) : 515 - 517
[29] NK cell tolerance and the maternal-fetal interface
Riley, Joan K.
Yokoyama, Wayne M.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2008, 59 (05) : 371 - 387
[30] Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsia
Luo, Fangyuan
Liu, Fulin
Guo, Yingzhe
Xu, Wenming
Li, Yilin
Yi, Jun
Fournier, Thierry
Degrelle, Severine
Zitouni, Hedia
Hernandez, Isabelle
Liu, Xinghui
Huang, Yu
Yue, Jun
FRONTIERS IN IMMUNOLOGY, 2023, 14

← 1 2 3 4 5 →