Advances in the study of HLA class Ib in maternal-fetal immune tolerance

被引:9
|
作者
Yang, Yiran [1 ]
Wang, Wanning [1 ]
Weng, Jing [2 ]
Li, Huifang [3 ]
Ma, Yanmin [4 ]
Liu, Lingyan [1 ]
Ma, Wei [2 ]
机构
[1] Capital Med Univ, Engn Res Ctr Endogenous Prophylact, Beijing Area Major Lab Peptide & Small Mol Drugs, Minist Educ China,Sch Pharmaceut Sci, Beijing, Peoples R China
[2] Capital Med Univ, Sch Basic Med Sci, Beijing, Peoples R China
[3] Capital Med Univ, Sch Tradit Chinese Med, Beijing, Peoples R China
[4] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金
北京市自然科学基金; 中国国家自然科学基金;
关键词
HLA class Ib; HLA-G; HLA-E; HLA-F; pregnancy; maternal-fetal immune tolerance; decidual immune cells; NATURAL-KILLER-CELLS; REGULATORY T-CELLS; ANTIGEN-PRESENTING CELLS; UTERINE NK CELLS; ACTIVATING RECEPTOR; INHIBITORY RECEPTOR; PREGNANCY SUCCESS; OPEN CONFORMERS; EXPRESSION; CD94/NKG2A;
D O I
10.3389/fimmu.2022.976289
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction.
引用
收藏
页数:12
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