A naphthalene exciplex based Al3+ selective on-type fluorescent probe for living cells at the physiological pH range: experimental and computational studies

被引：115

作者：

Banerjee, Arnab ^{[1
]}

Sahana, Animesh ^{[1
]}

Das, Sudipta ^{[1
]}

Lohar, Sisir ^{[1
]}

Guha, Subarna ^{[1
]}

Sarkar, Bidisha ^{[2
]}

Mukhopadhyay, Subhra Kanti ^{[2
]}

Mukherjee, Asok K. ^{[1
]}

Das, Debasis ^{[1
]}

机构：

[1] Univ Burdwan, Dept Chem, Burdwan 713104, W Bengal, India

[2] Univ Burdwan, Dept Microbiol, Burdwan 713104, W Bengal, India

来源：

ANALYST | 2012年 / 137卷 / 09期

关键词：

ALUMINUM TOXICITY; METAL-COMPLEXES; AB-INITIO; RECOGNITION; CHEMOSENSOR; CONTINUUM; SENSORS; PRINCIPLES; MOLECULES; DISEASE;

D O I：

10.1039/c2an16233d

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

2-((Naphthalen-6-yl)methylthio)ethanol (HL) was prepared by one pot synthesis using 2-mercaptoethanol and 2-bromomethylnaphthalene. It was found to be a highly selective fluorescent sensor for Al3+ in the physiological pH (pH 7.0-8.0). It could sense Al3+ bound to cells through fluorescence microscopy. Metal ions like Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Ag+, Cd2+, Hg2+, Cr3+ and Pb2+ did not interfere. No interference was also observed with anions like Cl-, Br-, F-, SO42-, NO3-, CO32-, HPO42- and SCN-. Experimentally observed structural and spectroscopic features of HL and its Al3+ complex have been substantiated by computational calculations using density functional theory (DFT) and time dependent density functional theory (TDDFT).

引用

页码：2166 / 2175

页数：10

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