Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man

被引：16

作者：

Henao-Martinez, Andres F. ^{[1
]}

Weinberg, Adriana ^{[1
]}

Waldman, W. James ^{[2
]}

Levi, Marilyn E. ^{[1
]}

机构：

[1] Univ Colorado Denver, Aurora, CO 80045 USA

[2] Ohio State Univ, Columbus, OH 43210 USA

来源：

JOURNAL OF CLINICAL VIROLOGY | 2012年 / 54卷 / 03期

关键词：

Herpes simplex virus; Proctitis; Leflunomide; IMMUNOSUPPRESSIVE AGENT LEFLUNOMIDE; CYTOMEGALOVIRUS DISEASE; IN-VIVO; TRANSPLANTATION; INHIBITION; REJECTION; THERAPY; NEPHROPATHY; CIDOFOVIR; CELLS;

D O I：

10.1016/j.jcv.2012.02.026

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human herpes simplex virus infections are very common and represent significant morbidity in the immunocompromised host. Patients with acyclovir resistant strains of HSV based on viral thymidine kinase gene mutations need alternative therapeutic approaches. Leflunomide has been shown to possess antiviral activity against several viruses. Herein we describe a case of acyclovir resistant HSV-2 proctitis in an HIV patient successfully treated with leflunomide without significant side effects. Published by Elsevier B.V.

引用

页码：276 / 278

页数：3

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