Palladium-Catalyzed Oxidative Aryltrifluoromethylation of Activated Alkenes at Room Temperature

被引：460
作者：
Mu, Xin [1 ]
Wu, Tao [1 ]
Wang, Hao-yang [2 ]
Guo, Yin-long [2 ]
Liu, Guosheng [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Mass Spectrometry Ctr, Shanghai 200032, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 02期
关键词：
FORMING REDUCTIVE ELIMINATION; BOND-FORMATION; ARYL IODIDES; C-O; TRIFLUOROMETHYLATION; DIAMINATION; FLUORINE; CONSTRUCTION; OXINDOLES; PD;
D O I：
10.1021/ja210614y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A palladium-catalyzed intramolecular oxidative aryltrifluoromethylation reaction of activated alkenes has been explored. The reaction allows for an efficient synthesis of a variety of CF3-containing oxindoles. Preliminary mechanistic study indicated that the reaction involves a C-sp(3)-Pd-IV(CF3) intermediate, which undergoes reductive elimination to afford a C-sp(3)-CF3 bond.
引用
收藏
页码：878 / 881
页数：4
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