Palladium-Catalyzed Oxidative Aryltrifluoromethylation of Activated Alkenes at Room Temperature

被引：459

作者：

Mu, Xin ^{[1
]}

Wu, Tao ^{[1
]}

Wang, Hao-yang ^{[2
]}

Guo, Yin-long ^{[2
]}

Liu, Guosheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Mass Spectrometry Ctr, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 02期

关键词：

FORMING REDUCTIVE ELIMINATION; BOND-FORMATION; ARYL IODIDES; C-O; TRIFLUOROMETHYLATION; DIAMINATION; FLUORINE; CONSTRUCTION; OXINDOLES; PD;

D O I：

10.1021/ja210614y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed intramolecular oxidative aryltrifluoromethylation reaction of activated alkenes has been explored. The reaction allows for an efficient synthesis of a variety of CF3-containing oxindoles. Preliminary mechanistic study indicated that the reaction involves a C-sp(3)-Pd-IV(CF3) intermediate, which undergoes reductive elimination to afford a C-sp(3)-CF3 bond.

引用

收藏

页码：878 / 881

页数：4

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