Overcoming nutrient limitations for cell-based production of influenza vaccine

被引:0
作者
Yousef, Sara [1 ,2 ]
Kovacsovics-Bankowski, Magdalena [1 ]
Salama, Mohamed E. [3 ,4 ]
Bhardwaj, Neelam [1 ]
Steinbach, Mary [1 ]
Langemo, Amanda [1 ]
Kovacsovics, Tibor [1 ]
Marvin, James [5 ]
Binder, Mascha [6 ]
Panse, Jens [7 ]
Kroeger, Nicolaus [2 ]
Luetkens, Tim [1 ,6 ]
Atanackovic, Djordje [1 ,6 ]
机构
[1] Univ Utah, Huntsman Canc Inst, Hematol & Hematol Malignancies, Salt Lake City, UT 84112 USA
[2] Univ Med Ctr Hamburg Eppendorf, Stem Cell Transplantat, Hamburg, Germany
[3] Univ Utah, ARUP Labs, Hematopathol, Salt Lake City, UT USA
[4] Univ Utah, Dept Pathol, Salt Lake City, UT USA
[5] Univ Utah, Hlth Sci Ctr, Flow Cytometry Core Facil, Salt Lake City, UT USA
[6] Univ Med Ctr Hamburg Eppendorf, Bone Marrow Transplantat Sect Pneumol, Oncol, Hematol, Hamburg, Germany
[7] Univ Hosp RWTH Aachen, Dept Med 4, Aachen, Germany
基金
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词
meidum optimization; metabolic analysis; process development; influenza virus production; MULTIPLE-MYELOMA; MAINTENANCE THERAPY; DEXAMETHASONE; CS1; TRANSPLANTATION; CONSOLIDATION; BORTEZOMIB; CYTOTOXICITY; THALIDOMIDE; TARGET;
D O I
10.1080/21645515.2015.1044182
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Metabolic analysis for medium optimization represents a very useful strategy in the process development of production of vaccines in cells. During influenza vaccine production, viruses hijack host cells and take advantage of host's metabolism. As a consequence, the nutritional demand of host cells should undergo a profound change, and usually more nutrients such as glucose and amino acids should be consumed. As such, the maintaining media used in virus production processes often cannot provide sufficient nutrients, and novel methods are urged to be established to address this severe issue of nutritional limitation. A detailed study on impacts of influenza virus on cell death and metabolism, with a profound analysis of nutritional requirements during virus production process, followed by a rational medium optimization is expected to be the most straightfoward and effective strategy. This would ensure a balanced and adequate nutritional supply, which should minimize cell death and improve both cell-specific virus yield and total influenza virus production. Such a metabolic analysis-based medium optimization would lay a solid foundation for the development of cell culture technology in influenza vaccine production.
引用
收藏
页码:1606 / 1611
页数:6
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