Recent advances in cancer stem cells

被引：197
作者：
Cho, Robert W. [1 ]
Clarke, Michael F. [1 ]
机构：
[1] Stanford Univ, Dept Pediat, Div Stem Cell Transplantat, Stanford Inst Stem Cell Biol & Regenerat Med, Palo Alto, CA 94304 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2008年 / 18卷 / 01期
关键词：
D O I：
10.1016/j.gde.2008.01.017
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The theory of cancer stem cells states that a subset of cancer cells within a tumor has the ability to self-renew and differentiate. Only those cells within a tumor that have these two properties are called cancer stem cells. This concept was first demonstrated in the study of leukemia where only cells with specific surface antigen profiles were able to cause leukemia when engrafted into immunodeficient mice. In recent years solid tumors were studied utilizing similar techniques in mice. Human tumors where evidence of cancer stem cells has been published include tumors of the breast, brain, pancreas, head and neck, and colon. If this difference in tumorigenicity of cancer cells also occurs in patients, then the ability to enrich for cancer stem cells lays an important groundwork for future studies where mechanisms involved in cancer stem cells can now be investigated.
引用
收藏
页码：48 / 53
页数：6
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