Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation

被引：82

作者：

Woo, Janghee ^{[1
]}

Lee, Juna ^{[1
,2
]}

Chae, Young Kwang ^{[1
]}

Kim, Myoung Sook ^{[1
]}

Baek, Jin Hyen ^{[3
,4
]}

Park, Jong Chul ^{[1
]}

Park, Min Joo ^{[1
]}

Smith, Ian M. ^{[1
]}

Trink, Barry ^{[1
]}

Ratovitski, Edward ^{[1
]}

Lee, Taekyul ^{[1
]}

Park, Bumsoo ^{[1
]}

Jang, Se Jin ^{[5
]}

Soria, Jean C. ^{[7
]}

Califano, Joseph A. ^{[1
]}

Sidransky, David ^{[1
,8
,9
]}

Moon, Chulso ^{[1
,2
,3
,4
,5
,6
,8
,9
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Program Human Genet, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Inst Cell Engn, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[5] Univ Ulsan, Asan Med Ctr, Dept Pathol, Seoul, South Korea

[6] Univ Ulsan, Asan Med Ctr, Dept Thorac Surg, Seoul, South Korea

[7] Inst Gustave Roussy, Div Canc Med, F-94805 Villejuif, France

[8] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[9] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA

来源：

CANCER LETTERS | 2008年 / 264卷 / 01期

关键词：

AQP5; aquaporins; overexpression;

D O I：

10.1016/j.canlet.2008.01.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Overexpression of several aquaporins has been reported in different types of human cancer but the role of AQPs in human carcinogenesis has not yet been clearly defined. Here, we demonstrate that ectopic expression of human AQP5 (hAQP5), a water channel expressed in lung, salivary glands, and kidney, induces many phenotypic changes characteristic of transformation both it? vitro and in vivo. Furthermore, the cell proliferative ability of AQP5 appears to be dependent upon the phosphorylation of a cAMP-protein kinase (PKA) consensus site located in a cytoplasmic loop of AQP5. In addition, phosphorylation of the PKA consensus site was found to be phosphorylated preferentially in tumors. These findings altogether indicate that hAQP5 plays an important role in human carcinogenesis and, furthermore, provide an attractive therapeutic target. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：54 / 62

页数：9

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