Biomarkers in cancer staging, prognosis and treatment selection

被引：1257

作者：

Ludwig, JA

Weinstein, JN ^{[1
]}

机构：

[1] NCI, Genom & Bioinformat Grp, Mol Pharmacol Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA

[2] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 11期

关键词：

D O I：

10.1038/nrc1739

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Advances in genomics, proteomics and molecular pathology have generated many candidate biomarkers with potential clinical value. Their use for cancer staging and personalization of therapy at the time of diagnosis could improve patient care. However, translation from bench to bedside outside of the research setting has proved more difficult than might have been expected. Understanding how and when biomarkers can be integrated into clinical care is crucial if we want to translate the promise into reality.

引用

页码：845 / 856

页数：12

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