Potential of curcumin loaded nanoparticles in ovarian cancer: Investigation using gynecological color Doppler ultrasound technique

Doppler ultrasonography is a type of medical ultrasonography that uses the Doppler effect to provide images of the movement of tissues and bodily fluids (typically blood) relative to the probe. To determine the potential of curcumin loaded nanoparticles in ovarian cancer which was diagnosed by using the gynecological color doppler ultrasound technique. Curcumin (CRMN) loaded chitosan nanoparticles were formulated using the ionotropic gelation method and characterized for particle size, zeta potential and polydispersity index (PDI). Clinical parameters like serum creatinine, blood serum urea nitrogen, resistance index and peak systolic velocity were evaluated. The drug loading efficiency was found between 11.38 to 17.45% with a particle size of 140-220nm. The zeta potential ranged between 19.12 to 23.14mV. Clinical parameters were found significantly changed when compared with before injection of CRMN-loaded nanoparticles. BUN was increased from 7.11 +/- 0.25to 28.27 +/- 6.65 mmol/L while SCr was also found to be increased from 52.71 +/- 3.14 mu mol/L to 312.20 +/- 40.41 mu mol/L. Collectively, these images of color doppler in animal model demonstrated efficient use in the diagnosis of ovarian cancer. This study confirms the potential of color doppler as an efficient medical imaging tool for ovarian cancer.