Interaction of long noncoding RNA MEG3 with miRNAs: A reciprocal regulation

被引：44

作者：

Moradi, Mohammad-Taher ^{[1
]}

Fallahi, Hossein ^{[1
,2
]}

Rahimi, Zohreh ^{[1
,3
]}

机构：

[1] Kermanshah Univ Med Sci, Med Biol Res Ctr, Daneshgah Ave,POB 67148-69914, Kermanshah, Iran

[2] Razi Univ, Sch Sci, Dept Biol, Bioinformat Lab, Kermanshah, Iran

[3] Kermanshah Univ Med Sci, Sch Med, Dept Clin Biochem, Kermanshah, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 03期

关键词：

competitive endogenous RNA; DNA methyltransferases; long noncoding RNA MEG3; microRNAs; EPITHELIAL-MESENCHYMAL TRANSITION; COMPETING ENDOGENOUS RNA; CISPLATIN RESISTANCE; CELL-PROLIFERATION; DOWN-REGULATION; UP-REGULATION; HEPATOCELLULAR-CARCINOMA; INHIBITS PROLIFERATION; PANCREATIC-CANCER; DNA METHYLATION;

D O I：

10.1002/jcb.27604

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The competitive endogenous RNA (ceRNA) hypothesis suggests that a long noncoding RNA (lncRNA) can function as sinks for pools of microRNAs (miRNAs); thereby, in the presence of ceRNA, messenger RNAs (mRNAs) targeted by specific miRNAs can liberate and translate to protein. Maternally expressed gene 3 (MEG3) is a lncRNA, which its expression has been detected in various normal tissues, while it is lost or downregulated in human tumors. The MEG3 is an imprinted gene which, is methylated and suppressed by DNA methyltransferases (DNMTs) family. Also, miRNAs are involved in the regulation of MEG3 gene expression. Interestingly, the lncRNA MEG3 (lnc-MEG3), as a ceRNA affects various cell processes such as proliferation, apoptosis, and angiogenesis by sponging miRNAs. These miRNAs, in turn, regulate different mRNAs in different pathways. This review focuses on the interaction between lnc-MEG3 and experimentally validated miRNAs. In addition, the discussion supplemented by some data obtained from mirPath (v.3) and TarBase (v.8) databanks to provide more details about the pathways affected by this ceRNA.

引用

页码：3339 / 3352

页数：14

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