Gastric floating matrix tablets: Design and optimization using combination of polymers

被引：40

作者：

Prajapati, Shailesh T. ^{[1
]}

Patel, Laxmanbhai D. ^{[2
]}

Patel, Dasharath M. ^{[1
]}

机构：

[1] Shri Sarvajanik Pharm Coll, Dept Pharmaceut, Mehsana 384001, Gujarat, India

[2] DDIT Pharm Coll, Dept Pharmaceut, Nadiad 387001, Gujarat, India

来源：

ACTA PHARMACEUTICA | 2008年 / 58卷 / 02期

关键词：

domperidone; floating matrix tablet; Box-Behnken design; GFDDS; release kinetics;

D O I：

10.2478/v10007-008-0006-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing domperidone as a model drug. Box-Behnken design was employed in formulating the GFDDS with three polymers: hydroxypropyl methylcellulose K4M (HPMC K4M) (X-1), Carbopol 934P (X-2) and sodium alginate (X-3), as independent variables. Floating lag time (FLT), total floating time (TFT), time required to release 50% of the drug (t(50)) and diffusion exponent (n) were selected as dependent variables. Seventeen formulations were prepared, dissolution data obtained was fitted to the power law and floating profiles were analyzed. HPMC loading was found to be significant for floating properties. Carbopol loading had a negative effect on floating properties but was found helpful in controlling the release rate of the drug. No significant effect of sodium alginate on floating properties was observed but it was important for gel formation. The quadratic mathematical model developed could be used to predict formulations with desired release and floating properties.

引用

页码：223 / 231

页数：9

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