Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies

被引：30

作者：

Kouijzer, Joop J. P. ^{[1
]}

Noordermeer, Danielle J. ^{[1
]}

van Leeuwen, Wouter J. ^{[2
]}

Verkaik, Nelianne J. ^{[3
]}

Lattwein, Kirby R. ^{[1
]}

机构：

[1] Erasmus MC Univ, Dept Biomed Engn, Thoraxctr, Med Ctr, Rotterdam, Netherlands

[2] Erasmus MC Univ, Dept Cardiothorac Surg, Med Ctr, Rotterdam, Netherlands

[3] Erasmus MC Univ, Dept Med Microbiol & Infect Dis, Med Ctr, Rotterdam, Netherlands

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

基金：

欧洲研究理事会;

关键词：

biofilm; cardiac device; diagnosis; infection; infective endocarditis; native valve; prosthetic valve; treatment; EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY; STAPHYLOCOCCUS-AUREUS ENDOCARDITIS; EXPERIMENTAL BACTERIAL-ENDOCARDITIS; POLYMERASE-CHAIN-REACTION; INTRACARDIAC ECHOCARDIOGRAPHY; IN-VITRO; F-18-FDG PET/CT; HEART-VALVES; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; MOLECULAR DIAGNOSIS;

D O I：

10.3389/fcell.2022.995508

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is increasing and mortality has not significantly improved despite technological advances. This review provides an updated overview using recent literature on the clinical presentation, diagnosis, imaging, causative pathogens, treatment, and outcomes in native valve, prosthetic valve, and cardiac device-related IE. In addition, the experimental approaches used in IE research to improve the understanding of disease mechanisms and the current diagnostic pipelines are discussed, as well as potential innovative diagnostic and therapeutic strategies. This will ultimately help towards deriving better diagnostic tools and treatments to improve IE patient outcomes.

引用

页数：23

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