Hydrogen sulfide intervention in focal cerebral ischemia/reperfusion injury in rats

被引：23

作者：

Li, Xin-juan ^{[1
]}

Li, Chao-kun ^{[1
]}

Wei, Lin-yu ^{[1
]}

Lu, Na ^{[1
]}

Wang, Guo-hong ^{[1
]}

Zhao, Hong-gang ^{[1
]}

Li, Dong-liang ^{[1
]}

机构：

[1] Xinxiang Med Univ, Dept Physiol & Neurobiol, Xinxiang, Henan Province, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2015年 / 10卷 / 06期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; brain injury; hydrogen sulfide; cerebral ischemia/reperfusion injury; P2X(7) receptor; 2,3,5-triphenyl-2H-tetrazolium chloride staining; animal model; protection; sodium hydrosulfide; immunofluorescence; middle cerebral artery occlusion; NSFC grant; neural regeneration; ARTERY OCCLUSION; RECEPTOR; BRAIN; MODEL; MODULATION; ISCHEMIA; PROTECTS; DISEASE;

D O I：

10.4103/1673-5374.158353

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The present study aimed to explore the mechanism underlying the protective effects of hydrogen sulfide against neuronal damage caused by cerebral ischemia/reperfusion. We established the middle cerebral artery occlusion model in rats via the suture method. Ten minutes after middle cerebral artery occlusion, the animals were intraperitoneally injected with hydrogen sulfide donor compound sodium hydrosulfide. Immunofluorescence revealed that the immunoreactivity of P2X(7) in the cerebral cortex and hippocampal CA1 region in rats with cerebral ischemia/reperfusion injury decreased with hydrogen sulfide treatment. Furthermore, treatment of these rats with hydrogen sulfide significantly lowered mortality, the Longa neurological deficit scores, and infarct volume. These results indicate that hydrogen sulfide may be protective in rats with local cerebral ischemia/reperfusion injury by down-regulating the expression of P2X(7) receptors.

引用

页码：932 / 937

页数：6

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