Salivary endothelin-1 potential for detecting oral cancer in patients with oral lichen planus or oral cancer in remission

被引:43
作者
Cheng, Yi-Shing Lisa [1 ]
Rees, Terry [2 ]
Jordan, Lee [1 ]
Oxford, Lance
O'Brien, John [3 ]
Chen, Huey-Shys [4 ]
Wong, David [5 ]
机构
[1] Baylor Coll Dent, Dept Diagnost Sci, Texas A&M Hlth Sci Ctr, Dallas, TX 75246 USA
[2] Baylor Coll Dent, Stomatol Ctr, Texas A&M Hlth Sci Ctr, Dallas, TX 75246 USA
[3] Baylor Univ, Med Ctr, Dept Surg, Dallas, TX 75246 USA
[4] Univ Med & Dent, Sch Nursing, Camden, NJ USA
[5] Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90024 USA
关键词
Oral cancer; Oral squamous cell carcinoma; Saliva; Endothelin; ET-1; Lichen planus; Biomarker; SQUAMOUS-CELL CARCINOMA; GINGIVAL EPITHELIAL-CELLS; SMOKING; DRINKING; POPULATION; BIOMARKERS; EXPRESSION; ALCOHOL; TOBACCO; DISEASE;
D O I
10.1016/j.oraloncology.2011.07.032
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Endothelin-1 (ET-1) is a potent vasoconstrictor involved not only in vascular biology but also in carcinogenesis. Results of a study in 2007 suggested salivary ET-1 as a potential biomarker for oral squamous cell carcinoma (OSCC), but a later study showed conflicting results. The purpose of our pilot study was to investigate feasibility of using salivary ET-1 as a biomarker for OSCC in two groups: oral lichen planus (OLP) patients and patients with OSCC in remission. Saliva samples were collected from five groups of subjects: patients with newly diagnosed, active OSCC (Group A); patients with OSCC in remission (Group B); patients with active OLP lesions (Group C); patients with OLP in remission (Group D); and normal controls (Group E). Salivary ET-1 levels were determined by enzyme-linked immunosorbent assay, and the results were analyzed by the Mann-Whitney U test. The mean salivary ET-1 level in Group A was significantly higher than that found in Group C (p = 0.001), Group D (p = 0.015) or Group E (p = 0.004). There were no significant differences (p > 0.05) in the mean salivary ET-1 levels between Groups A and B; Groups B and C; Groups B and D; Groups B and E; Groups C and D; Groups C and E; or Groups D and E. Salivary ET-1 could be a good biomarker for OSCC development in OLP patients regardless of the degree of OLP disease activity. However, it appeared not to be a good biomarker for detecting recurrence of OSCC in patients in remission. Published by Elsevier Ltd.
引用
收藏
页码:1122 / 1126
页数:5
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