Direct Asymmetric α-Allylation of Aldehydes with Simple Allylic Alcohols Enabled by the Concerted Action of Three Different Catalysts

被引：268

作者：

Jiang, Gaoxi ^{[1
]}

List, Benjamin ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 40期

关键词：

allylation; allylic alcohol; chiral counteranions; palladium; phosphates; TRANSITION-METAL CATALYSIS; DEHYDRATIVE ALLYLATION; PALLADIUM; ALKYLATION; ACID; SUBSTITUTION; EPOXIDATION; CONVERSION; LIGANDS; REGIO;

D O I：

10.1002/anie.201103263

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triple catalysis: The title reaction between α-branched aldehydes and allylic alcohols, which generates all-carbon quaternary stereogenic centers, constitutes the first asymmetric Tsuji-Trost-type α-allylation of carbonyl compounds with allylic alcohol (see scheme). This reaction is catalyzed by three different species, [Pd(PPh3)4], the chiral Brønsted acid TRIP, and benzhydryl amine. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9471 / 9474

页数：4

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