Safety of iron sucrose in hemodialysis patients intolerant to other parenteral iron products

被引:35
作者
Charytan, C [1 ]
Schwenk, MH [1 ]
Al-Saloum, MM [1 ]
Spinowitz, BS [1 ]
机构
[1] New York Hosp, Queens Med Ctr, Div Nephrol & Hypertens, Flushing, NY 11355 USA
来源
NEPHRON CLINICAL PRACTICE | 2004年 / 96卷 / 02期
关键词
iron sucrose; hemodialysis; iron dextran; sodium ferric gluconate;
D O I
10.1159/000076401
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background/Aims: This report summarizes the data gathered in four prospective studies of intravenous iron sucrose therapy administered to iron-deficient hemodialysis patients with a history of intolerance to other parenteral iron preparations. Methods: A total of 130 iron dextran- and/or sodium ferric gluconate-sensitive patients received intravenous iron sucrose therapy to correct iron deficiency, and/or maintain body iron stores. A history of intolerance to iron dextran alone was reported in 109 patients, to ferric sodium gluconate alone in 6 patients, and to both iron dextran and ferric sodium gluconate in 15 patients. Therapy with iron sucrose consisted of 100- or 200-mg doses administered undiluted intravenously over 2 - 5 min, or diluted in normal saline and infused over 15 - 30 min. Test doses of iron sucrose were not administered. The median cumulative dose was 1,000 mg, with a range of 100 - 5,000 mg. Results: There were no serious adverse events related to iron sucrose therapy in the 130 patients intolerant to other iron preparations. There were 14 nonserious drug-related adverse events in 8 patients attributed to iron sucrose, none of which resulted in discontinuation of therapy. These events were classified as either of severe ( diarrhea), moderate ( hypotension, nausea, vomiting), or mild severity ( constipation, dry mouth, skin irritation). Conclusion: Iron sucrose therapy is safe and well tolerated in hemodialysis patients intolerant to iron dextran and/or sodium ferric gluconate. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:C63 / C66
页数:4
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