A powerful new strategy for diversity-oriented synthesis of pyrroles from donor - Acceptor cyclopropanes and nitriles

被引：112

作者：

Yu, M ^{[1
]}

Pagenkopf, BL ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 26期

关键词：

D O I：

10.1021/ol036180+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Lewis acid activated donor-acceptor cyclopropanes react with aliphatic, aromatic, and alpha,beta-unsaturated nitriles in a novel cascade [3 + 2] dipolar cycloaddition, dehydration, and tautomerization sequence to afford pyrroles in moderate to excellent overall yield. This cost-effective and regiospecific method is ideally suited for the preparation of combinatorial libraries.

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页码：5099 / 5101

页数：3

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