High resolution read-out circuit for DNA label-free detection system

被引：0

作者：

De Venuto, Daniela ^{[1
]}

Ricco, Bruno ^{[2
]}

机构：

[1] DEE Politecn Bari, Bari, Italy

[2] Univ Bologna, DEIS, Bologna, Italy

来源：

ISQED 2008: PROCEEDINGS OF THE NINTH INTERNATIONAL SYMPOSIUM ON QUALITY ELECTRONIC DESIGN | 2008年

关键词：

DNA biosensor read-out; charge sensitive front-end; differential read-out system;

D O I：

10.1109/ISQED.2008.153

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridization effect is monitored by means of a charge sensitive amplifier and a differential stage. The systems provide an AID conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensors.

引用

页码：708 / +

页数：2

共 5 条

[1] Sensitive immunodetection through impedance measurements onto gold functionalized electrodes [J].

Ameur, S ;

Martelet, C ;

Jaffrezic-Renault, N ;

Chovelon, JM .

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2000, 89 (2-3) :161-170

[2]

Berggren C, 1999, ELECTROANAL, V11, P156, DOI 10.1002/(SICI)1521-4109(199903)11:3<156::AID-ELAN156>3.0.CO

[3]

2-O

[4]

BERGGREN C, 2001, ELECTROANALYSIS, V13

[5] Direct immunosensing using differential electrochemical measurements of impedimetric variations [J].

Maupas, H ;

Soldatkin, AP ;

Martelet, C ;

JaffrezicRenault, N ;

Mandrand, B .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1997, 421 (1-2) :165-171

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