SARS-CoV-2 variants- Evolution, spike protein, and vaccines

被引：35

作者：

Chen, Kai-Wei K. ^{[1
]}

Huang, Daniel Tsung-Ning ^{[1
,2
]}

Huang, Li -Min ^{[3
,4
]}

机构：

[1] MacKay Childrens Hosp, Dept Pediat, Taipei, Taiwan

[2] MacKay Med Coll, Dept Med, Taipei, Taiwan

[3] Natl Taiwan Univ, Natl Taiwan Univ Childrens Hosp, Dept Pediat, Coll Med, Taipei, Taiwan

[4] Natl Taiwan Univ, Natl Taiwan Univ Childrens Hosp, Dept Pediat, Coll Med, 8 Zhongshan S Rd, Taipei, Taiwan

来源：

BIOMEDICAL JOURNAL | 2022年 / 45卷 / 04期

关键词：

COVID-19; SARS-CoV-2; Spike mutations; Variant of concern; Vaccines; RECEPTOR-BINDING DOMAIN; CHADOX1; NCOV-19; COVID-19; MUTATIONS; BNT162B2; B.1.1.7; BOOST; P.1;

D O I：

10.1016/j.bj.2022.04.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite the rising natural and vaccines mediated immunity, several countries have experienced a resurgence of the Coronavirus disease of 2019 (COVID-19) due to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. From Alpha to Omicron, the variants of concern (VOC) have evolved several spike protein mutations that may have an impact on virus characteristics, such as transmissibility and antigenicity. In this review, we describe the evolution of SARS-CoV-2, summarize current knowledge of epidemiological and clinical features of the variants, and discuss the response strategies in terms of vaccines to reduce the burden of COVID-19.

引用

页码：573 / 579

页数：7

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