Syntheses of curcumin bioconjugates and study of their antibacterial activities against β-lactamase-producing microorganisms

被引：67

作者：

Kumar, S

Narain, U

Tripathi, S

Misra, K ^{[1
]}

机构：

[1] Univ Allahabad, Dept Chem, Nucle Acids Res Lab, Allahabad 211002, Uttar Pradesh, India

[2] Kammala Nehru Mem Hosp, Dept Pathol, Allahabad 211002, Uttar Pradesh, India

来源：

BIOCONJUGATE CHEMISTRY | 2001年 / 12卷 / 04期

关键词：

D O I：

10.1021/bc0000482

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study cucumin bioconjugates, viz. di-O-glycinoylcurcumin (I), di-O-glycinoyl-C-4-glycylcurcumin (II), 5'-deoxy-5'-curcuminylthymidine (5'-cur-T) (IV), and 2'-deoxy-2'-curcuminyluridine (2'-cur-U) (V) have been synthesized and characterized by elemental analysis and H-1 NMR. The turmeric peptide (Tp) was isolated from the aqueous turmeric extract of the turmeric rhizome. The antibacterial activity of these four bioconjugates and also of the turmeric peptide and sodium salt of curcumin (III) have been tested particularly for beta -lactamase-producing microorganisms.

引用

页码：464 / 469

页数：6

共 28 条

[1] PHARMACOLOGY OF CURCUMA-LONGA [J].