Protein export and drug efflux through bacterial channel-tunnels

被引：46

作者：

Andersen, C ^{[1
]}

Hughes, C ^{[1
]}

Koronakis, V ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0955-0674(00)00229-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The bacterial protein TolC assembles into an a-helical trans-periplasmic tunnel, which is embedded in the outer membrane by a contiguous beta -barrel channel. TolC and its homologues thus provide large exit ducts for a wide range of substrates, including protein toxins and antibacterial drugs, that are engaged by specific recognition proteins in the cytosolic membrane.

引用

页码：412 / 416

页数：5

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