PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction

被引：31
作者：
Campa, Carlo C. [1 ]
Franco, Irene [1 ]
Hirsch, Emilio [1 ]
机构：
[1] Univ Torino, MBC, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy
来源：
FEBS LETTERS | 2015年 / 589卷 / 14期
关键词：
Phosphoinositide; Class II alpha-isoform of phosphatidylinositol 3-kinase; PI3K-C2; alpha; Endocytosis; Exocytosis; Signal transduction; Vesicle trafficking; II PHOSPHOINOSITIDE 3-KINASE; CLATHRIN-MEDIATED ENDOCYTOSIS; TRANS-GOLGI NETWORK; PHOSPHATIDYLINOSITOL; 3-KINASE; ALPHA-ISOFORM; C2; DOMAIN; SUBSTRATE-SPECIFICITY; ENDOTHELIAL-CELLS; MEMBRANE DYNAMICS; RAB5; EFFECTORS;
D O I：
10.1016/j.febslet.2015.05.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The spatial restriction of phosphorylated phosphoinositides generated downstream activated membrane receptors is critical for proper cell response to environmental cues. The alpha isoform of class II PI3Ks, PI3K-C2 alpha, has emerged as a modulator of receptor localization, acting both in the control of receptor endocytosis and resensitization. This unexpectedly versatile enzyme was found to differentially produce two distinct 3-phosphorylated phosphoinositides and to selectively control distinct steps of vesicular traffic such as endocytosis and recycling. This review focuses on the latest discoveries regarding PI3K-C2 alpha function in vesicle trafficking and its impact on cell biology and mammalian embryonic development. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1552 / 1558
页数：7
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