PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction

被引：31
作者：
Campa, Carlo C. [1 ]
Franco, Irene [1 ]
Hirsch, Emilio [1 ]
机构：
[1] Univ Torino, MBC, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy
来源：
FEBS LETTERS | 2015年 / 589卷 / 14期
关键词：
Phosphoinositide; Class II alpha-isoform of phosphatidylinositol 3-kinase; PI3K-C2; alpha; Endocytosis; Exocytosis; Signal transduction; Vesicle trafficking; II PHOSPHOINOSITIDE 3-KINASE; CLATHRIN-MEDIATED ENDOCYTOSIS; TRANS-GOLGI NETWORK; PHOSPHATIDYLINOSITOL; 3-KINASE; ALPHA-ISOFORM; C2; DOMAIN; SUBSTRATE-SPECIFICITY; ENDOTHELIAL-CELLS; MEMBRANE DYNAMICS; RAB5; EFFECTORS;
D O I：
10.1016/j.febslet.2015.05.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The spatial restriction of phosphorylated phosphoinositides generated downstream activated membrane receptors is critical for proper cell response to environmental cues. The alpha isoform of class II PI3Ks, PI3K-C2 alpha, has emerged as a modulator of receptor localization, acting both in the control of receptor endocytosis and resensitization. This unexpectedly versatile enzyme was found to differentially produce two distinct 3-phosphorylated phosphoinositides and to selectively control distinct steps of vesicular traffic such as endocytosis and recycling. This review focuses on the latest discoveries regarding PI3K-C2 alpha function in vesicle trafficking and its impact on cell biology and mammalian embryonic development. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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收藏
页码：1552 / 1558
页数：7
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