Etiopathogenesis of alopecia areata: Why do our patients get it?

被引：45
|
作者：
Wang, Eddy [1 ]
McElwee, Kevin J. [1 ,2 ]
机构：
[1] Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC V5Z 4E8, Canada
[2] Vancouver Coastal Hlth Res Inst, Vancouver, BC V5Z 4E8, Canada
来源：
DERMATOLOGIC THERAPY | 2011年 / 24卷 / 03期
基金：
加拿大健康研究院;
关键词：
alopecia areata; autoimmune disease; disease pathogenesis; C3H/HEJ MOUSE MODEL; HELPFUL DIAGNOSTIC FEATURE; HUMAN SCALP EXPLANTS; IN-VIVO DEPLETION; HAIR FOLLICLE; IMMUNE PRIVILEGE; AUTOIMMUNE-DISEASE; T-CELLS; DEBR MODEL; CYTOMEGALOVIRUS DNA;
D O I：
10.1111/j.1529-8019.2011.01416.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Alopecia areata (AA) is a nonscarring, inflammatory skin disease that results in patchy hair loss. AA is unpredictable in its onset, severity, and duration making it potentially very stressful for affected individuals. Currently, the treatment options for AA are limited and the efficacy of these treatments varies from patient to patient. The exact etiology of AA is unknown. This article provides some insights into the etiopathogenesis of AA and why some people develop it. The current knowledge on the pathogenesis of AA is summarized and some of the recent hypotheses and studies on AA are presented to allow for a fuller understanding of the possible biological mechanisms of AA.
引用
收藏
页码：337 / 347
页数：11
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