Identification of a Glycosyltransferase from Mycobacterium marinum Involved in Addition of a Caryophyllose Moiety in Lipooligosaccharides

被引：19

作者：

Sarkar, Debasmita ^{[1
]}

Sidhu, Mandeep ^{[1
]}

Singh, Albel ^{[1
]}

Chen, Jiemin ^{[1
]}

Lammas, David A. ^{[2
]}

van der Sar, Astrid M. ^{[3
]}

Besra, Gurdyal S. ^{[1
]}

Bhatt, Apoorva ^{[1
]}

机构：

[1] Univ Birmingham, Coll Life & Environm Sci, Sch Biosci, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Coll Med & Dent Sci, Div Immun & Infect, Birmingham B15 2TT, W Midlands, England

[3] Vrije Univ Amsterdam Med Ctr, Dept Med Microbiol & Infect Control, NL-1081 BT Amsterdam, Netherlands

来源：

JOURNAL OF BACTERIOLOGY | 2011年 / 193卷 / 09期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

GENE-CLUSTER; TUBERCULOSIS; VIRULENCE; BIOSYNTHESIS; SECRETION; ENVELOPE; FAMILY; MMPL8; BCG;

D O I：

10.1128/JB.00065-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Deletion of Mycobacterium marinum MMAR2333 resulted in the loss of three of four subclasses of lipooligosaccharides (LOSs). The mutant was unable to extend an intermediate (LOS-II*) by addition of caryophyllose. These data and the predicted domain structure suggest that MMAR2333 is a glycosyltransferase involved in the generation of a lipid-linked caryophyllose donor.

引用

页码：2336 / 2340

页数：5

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