Physical Activity and HIV: Effects on Fitness Status, Metabolism, Inflammation and Immune-Activation

被引：13

作者：

Ceccarelli, Giancarlo ^{[1
]}

Pinacchio, Claudia ^{[1
]}

Santinelli, Letizia ^{[2
]}

Adami, Paolo Emilio ^{[3
,4
]}

Borrazzo, Cristian ^{[1
]}

Cavallari, Eugenio Nelson ^{[1
]}

Vullo, Annamaria ^{[1
]}

Innocenti, Giuseppe Pietro ^{[1
]}

Mezzaroma, Ivano ^{[5
]}

Mastroianni, Claudio Maria ^{[1
]}

d'Ettorre, Gabriella ^{[1
]}

机构：

[1] Univ Rome Sapienza, Dept Publ Hlth & Infect Dis, Viale Policlin 155, I-00161 Rome, Italy

[2] Univ Rome Sapienza, Virol Lab, Dept Mol Med, Rome, Italy

[3] Univ Rome Sapienza, Exercise Physiol Lab, Dept Physiol & Pharmacol, Rome, Italy

[4] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, Rome, Italy

[5] Univ Rome Sapienza, Dept Clin Med, Rome, Italy

来源：

AIDS AND BEHAVIOR | 2020年 / 24卷 / 04期

关键词：

HIV; Physical activity; Life style; Sport; Immune-activation; Metabolism; BODY-FAT; EXERCISE; ADIPONECTIN; LEPTIN; HEALTH; DIET; ATHEROSCLEROSIS; ASSOCIATION; STRATEGIES; BIOMARKERS;

D O I：

10.1007/s10461-019-02510-y

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Several studies evidenced that a sedentary lifestyle is related with higher levels of systemic inflammation and highlighted that physical activity can trigger anti-inflammatory effects. To evaluate the impact of self-prescribed physical activity on fitness status, metabolism, inflammation and immune-activation in people living with HIV, an interim analysis of the results of the clinical trial PRIMO (NCT03392805) was performed. Patients enrolled were divided in 2 groups on the basis of self-prescribed physical activity: a physically active group (self-prescribed physical activity) and a sedentary group. Physical fitness was evaluated by sport medicine specialists and related to nutritional status, anthropometric variables, adipokines levels (adiponectin, leptin, resistin), peripheral immune-activation (CD38, HLA-DR on CD4 and CD8), and plasma inflammatory markers (IL-6 and TNF-alpha). The physically active group had a better profile in anthropometric measures and aerobic fitness but did not show lower levels of immune-activation compared to sedentary group. Also serum IL-6, TNF-alpha, and adipokines levels showed no statistical differences. On the basis of these data, a regular self-organized physical activity seems useful to improve cardio-respiratory fitness, but unable to control HIV-related immune-activation.

引用

页码：1042 / 1050

页数：9

共 52 条

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