Recent advances in breast cancer metastasis suppressor 1

被引:15
|
作者
Chen, Xiuping [1 ]
Xu, Zengtao [1 ]
Wang, Yitao [1 ]
机构
[1] Univ Macau, Inst Chinese Med Sci, Taipa, Macau, Peoples R China
来源
关键词
BRMS1; Gap junctional intercellular communication; mSin3-HDAC; microRNA; NF-kappa B; CELL LUNG-CANCER; JUNCTIONAL INTERCELLULAR COMMUNICATION; NF-KAPPA-B; CARCINOMA METASTASIS; DEACETYLASE COMPLEX; MURINE ORTHOLOG; GENE-EXPRESSION; MESSENGER-RNA; GAP-JUNCTIONS; BRMS1;
D O I
10.5301/JBM.2011.6267
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Metastasis is a complex process divided into a number of steps including detachment of tumor cells from the primary tumor, invasion, migration, intravasation, survival in the vasculature, extravasation, and colonization of the secondary site. Proteins that block metastasis without inhibiting primary tumor formation are known as metastasis suppressors; examples are NM23, Maspin, KAI1, KISS1, and MKK4. Breast cancer metastasis suppressor 1 (BRMS1) was identified as a suppressor of breast cancer metastasis in the late 1990s. In vitro and in vivo studies have confirmed that BRMS1 is a potent metastasis suppressor not limited to breast cancer. However, conflicting clinical observations regarding its role as a metastasis suppressor and its validity as a diagnostic biomarker warrant more in-depth clinical study. In this review, the authors provide an overview of its biology, function, action mechanism and pathological significance.
引用
收藏
页码:1 / 8
页数:8
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