An efficient synthesis of trace amine-associated receptor agonist [1-14C]tyramine

被引：0
|
作者：
Filer, Crist N. [1 ]
Orphanos, Demetri [1 ]
机构：
[1] PerkinElmer Hlth Sci Inc, Custom Synth, Waltham, MA USA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2019年 / 62卷 / 01期
关键词：
carbon-14; trace amine; tyramine; PHARMACOLOGY;
D O I：
10.1002/jlcr.3671
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The 2-step synthesis of [1-C-14]tyramine hydrochloride is described with the product being characterized by TLC, HPLC, and UV spectroscopy. Several methods are provided to purify [1-C-14]tyramine hydrochloride, and its storage and stability are also discussed.
引用
收藏
页码：24 / 27
页数：4
相关论文
共 29 条
  • [1] Trace amine-associated receptor 1 - Family archetype or iconoclast?
    Grandy, David K.
    PHARMACOLOGY & THERAPEUTICS, 2007, 116 (03) : 355 - 390
  • [2] Tyramine and -phenylethylamine, from fermented food products, as agonists for the human trace amine-associated receptor 1 (hTAAR1) in the stomach
    Ohta, Hiroto
    Takebe, Youhei
    Murakami, Yuka
    Takahama, Yusei
    Morimura, Shigeru
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2017, 81 (05) : 1002 - 1006
  • [3] Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands
    Hu, Liaoyuan A.
    Zhou, Tian
    Ahn, Jinwoo
    Wang, Shuli
    Zhou, Julia
    Hu, Yi
    Liu, Qingyun
    BIOCHEMICAL JOURNAL, 2009, 424 : 39 - 45
  • [4] Discovery of trace amine-associated receptor 1 ligands by molecular docking screening against a homology model
    Lam, V. M.
    Rodriguez, D.
    Zhang, T.
    Koh, E. J.
    Carlsson, J.
    Salahpour, A.
    MEDCHEMCOMM, 2015, 6 (12) : 2216 - 2223
  • [5] A rapid functional assay for the human trace amine-associated receptor 1 based on the mobilization of internal calcium
    Navarro, Hernan A.
    Gilmour, Brian P.
    Lewin, Anita H.
    JOURNAL OF BIOMOLECULAR SCREENING, 2006, 11 (06) : 688 - 693
  • [6] The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity
    Miller, Gregory M.
    JOURNAL OF NEUROCHEMISTRY, 2011, 116 (02) : 164 - 176
  • [7] Trace Amine-Associated Receptor 1 (TAAR1): Molecular and Clinical Insights for the Treatment of Schizophrenia and Related Comorbidities
    Nair, Pramod C.
    Chalker, Justin M.
    McKinnon, Ross A.
    Langmead, Christopher J.
    Gregory, Karen J.
    Bastiampillai, Tarun
    ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2022, 5 (03) : 183 - 188
  • [8] Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, L-DOPA Responsivity, and Glutamatergic Neurotransmission
    Alvarsson, Alexandra
    Zhang, Xiaoqun
    Stan, Tiberiu L.
    Schintu, Nicoletta
    Kadkhodaei, Banafsheh
    Millan, Mark J.
    Perlmann, Thomas
    Svenningsson, Per
    JOURNAL OF NEUROSCIENCE, 2015, 35 (41): : 14057 - 14069
  • [9] Actions of Trace Amines in the Brain-Gut-Microbiome Axis via Trace Amine-Associated Receptor-1 (TAAR1)
    Bugda Gwilt, Katlynn
    Gonzalez, Dulce Pamela
    Olliffe, Neva
    Oller, Haley
    Hoffing, Rachel
    Puzan, Marissa
    El Aidy, Sahar
    Miller, Gregory M.
    CELLULAR AND MOLECULAR NEUROBIOLOGY, 2020, 40 (02) : 191 - 201
  • [10] In Vitro Activation of Human Adrenergic Receptors and Trace Amine-Associated Receptor 1 by Phenethylamine Analogues Present in Food Supplements
    Pinckaers, Nicole E. T.
    Blankesteijn, W. Matthijs
    Mircheva, Anastasiya
    Shi, Xiao
    Opperhuizen, Antoon
    van Schooten, Frederik-Jan
    Vrolijk, Misha F.
    NUTRIENTS, 2024, 16 (11)
123