New fibroblast activation protein inhibitor, CPD60, attenuates fibrosis and chronic liver disease progresion in CCL4 induced liver fibrosis, but not in MDR2-/- mice

被引:0
作者
Yang, Ai Ting [1 ,2 ,3 ]
Kim, Yong Ook [2 ,3 ]
Aslam, Misbah [2 ,3 ]
Giardino, Mariacristina [2 ,3 ]
Abe, Hiroyuki [2 ,3 ]
Park, Kyoung Sook [2 ,3 ]
Khan, Muhammad Ashfaq [2 ,3 ]
You, Hong [1 ]
Jia, Ji Dong [1 ]
Klein, Thomas [4 ]
Schuppan, Detlef [2 ,3 ,5 ]
机构
[1] Capital Med Univ, Beijing Friendship Hosp, Expt & Translat Res Ctr, Beijing, Peoples R China
[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Translat Immunol, Mainz, Germany
[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Res Ctr Immunotherapy FZI, Mainz, Germany
[4] Boehringer Ingelheim GmbH & Co KG, Cardiometabol Res, Biberach, Germany
[5] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Gastroenterol, Boston, MA 02115 USA
关键词
D O I
10.1016/S0618-8278(19)30384-6
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
THU-104
引用
收藏
页码:E206 / E206
页数:1
相关论文
共 50 条
[21]   HEDGEHOG PATHWAY INHIBITOR IS A SAFE AND EFFECTIVE TREATMENT FOR HEPATOCELLULAR CARCINOMA IN MDR2-/- MICE WITH CHRONIC LIVER DISEASE [J].
Schroder, Vanessa T. ;
Rangwala, Fatima ;
Syn, Wing-Kin ;
Guy, Cynthia D. ;
Karaca, Gamze F. ;
Diehl, Anna Mae .
HEPATOLOGY, 2010, 52 (04) :1146A-1146A
[22]   Targeted disruption of TGF-B activation by an AVB1 integrin inhibitor significantly reduces liver fibrosis in CCl4 mice and Human NASH liver slices [J].
Schaub, Johanna ;
Decaris, Martin ;
Reilly, Maureen ;
Lee, Gail ;
Martin, Shamra ;
Rao, Vickram ;
Chen, Chun ;
Rexhepaj, Meghi ;
Kotak, Perna ;
Hooi, Lisa ;
Leftheris, Katarina ;
Cha, Jake ;
Lepist, Irene ;
Andre, Patrick ;
Turner, Scott .
JOURNAL OF HEPATOLOGY, 2019, 70 (01) :E57-E58
[23]   Anthocyanins isolated from blueberry ameliorates CCl4 induced liver fibrosis by modulation of oxidative stress, inflammation and stellate cell activation in mice [J].
Sun, Jianchao ;
Wu, Yafeng ;
Long, Cuizhen ;
He, Ping ;
Gu, Junying ;
Yang, Lei ;
Liang, Yaodong ;
Wang, Yuping .
FOOD AND CHEMICAL TOXICOLOGY, 2018, 120 :491-499
[24]   PHARMACOLOGICAL EFFECTS OF ACETYL SALICYLIC ACID, SULFASALAZINE, IBUPROFEN AND CELECOXIB ON LIVER FIBROSIS INDUCED BY CHRONIC ADMINISTRATION OF CCL4 [J].
Chavez, E. ;
Moreno, M. G. ;
Muriel, P. .
JOURNAL OF HEPATOLOGY, 2009, 50 :S272-S272
[25]   Collagen-binding vascular endothelial growth factor attenuates CCl4-induced liver fibrosis in mice [J].
Wu, Kangkang ;
Huang, Rui ;
Wu, Hongyan ;
Liu, Yong ;
Yang, Chenchen ;
Cao, Shufeng ;
Hou, Xianglin ;
Chen, Bing ;
Dai, Jianwu ;
Wu, Chao .
MOLECULAR MEDICINE REPORTS, 2016, 14 (05) :4680-4686
[26]   The heat shock protein 90 inhibitor, 17-AAG, attenuates thioacetamide induced liver fibrosis in mice [J].
Abu-Elsaad, Nashwa M. ;
Serrya, Marwa S. ;
El-Karef, Amr M. ;
Ibrahim, Tarek M. .
PHARMACOLOGICAL REPORTS, 2016, 68 (02) :275-282
[27]   The heat shock protein 90 inhibitor, 17-AAG, attenuates thioacetamide induced liver fibrosis in mice [J].
Nashwa M. Abu-Elsaad ;
Marwa S. Serrya ;
Amr M. El-Karef ;
Tarek M. Ibrahim .
Pharmacological Reports, 2016, 68 :275-282
[28]   Resolvin D1 attenuates CCl4 Induced Liver Fibrosis by Inhibiting Autophagy-Mediated HSC activation via AKT/mTOR Pathway [J].
Li, Jiahuan ;
Deng, Xiaoling ;
Wang, Shuhan ;
Jiang, Qianqian ;
Xu, Keshu .
FRONTIERS IN PHARMACOLOGY, 2021, 12
[29]   NOX1/4 Inhibition Attenuates Myofibroblast Activation and Liver Fibrosis in MDR2 Deficient Mice, a Model of Progressive Cholangiopathy [J].
Nishio, Takahiro ;
Liang, Shuang ;
Mccubbin, Ryan ;
Kisseleva, Tatiana ;
Brenner, David A. .
HEPATOLOGY, 2018, 68 :642A-643A
[30]   GUT-DERIVED BACTERIAL PRODUCTS DRIVE PROGRESSION OF LIVER FIBROSIS IN MDR2-/- MICE: INVOLVEMENT OF LPS AND TLR4 [J].
Poelstra, Klaas ;
Popov, Yury ;
Sverdlov, Deanna Y. ;
Sharma, Anisha ;
Schuppan, Detlef .
HEPATOLOGY, 2009, 50 (04) :819A-819A