Chain length-specific properties of ceramides

被引：392

作者：

Groesch, Sabine ^{[1
]}

Schiffmann, Susanne ^{[1
]}

Geisslinger, Gerd ^{[1
]}

机构：

[1] Klinikum Johann Wolfgang Goethe Univ Frankfurt, Inst Klin Pharmakol, Pharmazentrum Frankfurt ZAFES, D-60590 Frankfurt, Germany

来源：

PROGRESS IN LIPID RESEARCH | 2012年 / 51卷 / 01期

关键词：

Ceramide; Ceramide synthase; Chain length-specific; Apoptosis; Cancer; PROTEIN PHOSPHATASE 2A; LONGEVITY ASSURANCE GENE-1; RADIATION-INDUCED APOPTOSIS; TANDEM MASS-SPECTROMETRY; SQUAMOUS-CELL CARCINOMAS; COLON-CANCER CELLS; KINASE C-ZETA; CYSTIC-FIBROSIS; LONG-CHAIN; SPHINGOLIPID SYNTHESIS;

D O I：

10.1016/j.plipres.2011.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ceramides are a class of sphingolipids that are abundant in cell membranes. They are important structural components of the membrane but can also act as second messengers in various signaling pathways. Until recently, ceramides and dihydroceramides were considered as a single functional class of lipids and no distinction was made between molecules with different chain lengths. However, based on the development of high-throughput, structure-specific and quantitative analytical methods to measure ceramides, it has now become clear that in cellular systems the amounts of ceramides differ with respect to their chain length. Further studies have indicated that some functions of ceramides are chain-length dependent. In this review, we discuss the chain length-specific differences of ceramides including their pathological impact on Alzheimer's disease, inflammation, autophagy, apoptosis and cancer. (c) 2011 Elsevier Ltd. All rights reserved.

引用

页码：50 / 62

页数：13

共 152 条

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