Reversal of neuromuscular block in companion animals

被引：11

作者：

Jones, Ronald S. ^{[1
]}

Auer, Ulrike ^{[2
]}

Mosing, Martina ^{[3
]}

机构：

[1] Univ Liverpool, Sch Vet Sci, Neston, England

[2] Vet Univ Vienna, Clin Anaesthesiol & Perioperat Intens Care Med, A-1030 Vienna, Austria

[3] Univ Zurich, Vetsuisse Fac, Div Anaesthesiol, CH-8057 Zurich, Switzerland

来源：

VETERINARY ANAESTHESIA AND ANALGESIA | 2015年 / 42卷 / 05期

关键词：

edrophonium; monitoring; neostigmine; residual neuromuscular block; sugammadex; INDUCED MUSCLE-RELAXATION; NEOSTIGMINE ANTAGONISM; CLINICAL-OBSERVATIONS; VOLATILE ANESTHETICS; PROFOUND ROCURONIUM; GAMMA-CYCLODEXTRIN; RESIDUAL PARALYSIS; SUGAMMADEX; VECURONIUM; EDROPHONIUM;

D O I：

10.1111/vaa.12272

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

ObjectiveTo review the evidence regarding the reversal of neuromuscular block (NMB) in companion animals with emphasis on the development and use of newer agents. Database usedData sources include scientific reviews and original research publications in both human and veterinary literature using Pubmed and Scopus as search data bases. Unpublished and locally published data on reversal of NMB are presented. ConclusionsResidual NMB has been shown to increase morbidity and mortality in humans and needs to be avoided. It can be detected only by adequate neuromuscular monitoring. The proper use of reversal agents avoids residual NMB and recurarization should not occur. Anticholinesterase inhibitors, such as edrophonium and neostigmine have been used to reverse NMB when the need for this has been established. Reversal is influenced by several factors and a number of undesirable side- effects of these drugs have been reported. Sugammadex, a -cyclodextrin, which was designed specifically to encapsulate rocuronium, is more rapid in its actions, has fewer side effects and can reverse profound NMB induced by aminosteroidal muscle relaxants.

引用

页码：455 / 471

页数：17